CHARACTERIZATION OF MAIT CELL FUNCTION AND FREQUENCY AT THE RECTAL MUCOSA AND GASTROINTESTINAL TRACT DURING HIV/SIV INFECTION
Grant number: 1123673 | Funding period: 2017 - 2021
This project focuses on determining how HIV infection alters the function of rare, unconventional immune cell populations in the gastrointestinal tract. These cells are not well described in humans or primate models of HIV infection, but we will determine whether these cells are depleted by HIV infection and whether there are interventions that can boost the function of these cells in order better fight HIV infection.
Related publications (9)
Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
Priyanka Chaurasia, Thi HO Nguyen, Louise C Rowntree, Jennifer A Juno, Adam K Wheatley, Stephen J Kent, Katherine Kedzierska, Jamie Rossjohn, Jan Petersen
CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-..
SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph
Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
David S Khoury, Deborah Cromer, Arnold Reynaldi, Timothy E Schlub, Adam K Wheatley, Jennifer A Juno, Kanta Subbarao, Stephen J Kent, James A Triccas, Miles P Davenport
Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the fut..
CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..
Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype
Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen
An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..
Distinct systems serology features in children, elderly and COVID patients
Kevin Selva, Carolien van de Sandt, Melissa Lemke, Christina Lee, Suzanne Shoffner, Brendon Chua, Thi HO Nguyen, Louise Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, David Jackson, Katie Flanagan, Jane Crowe, Allen Cheng, Denise Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran
SARS-CoV-2, the pandemic coronavirus that causes COVID-19, has infected millions worldwide, causing unparalleled social and econom..