ENHANCING THE ANTI-CANCER IMMUNE RESPONSE BY COMBINING RADIOTHERAPY AND IMMUNOTHERAPY

Grant number: 1122347 | Funding period: 2017 - 2020

Completed

Abstract

Lung cancer is the biggest cause of cancer related death in Australia. Recently, immune therapies have shown promise by unlocking the body’s own defenses to fight against lung cancer. I aim to maximise the effect of the anti-PD-1 immune therapy by ‘kick-starting’ the immune response with high-precision stereotactic ablative body radiotherapy (SABR). By completing clinical trials and biological research into the combination of therapies I hope to improve outcomes for patients with lung cancer.

Related publications (6)

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The Emerging Role of Extracranial Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma: A Systematic Review.

Jennifer Le Guevelou, Paul Sargos, Shankar Siva, Guillaume Ploussard, Piet Ost, Silke Gillessen, Thomas Zilli

2023-01-01

CONTEXT: Although the management of metastatic renal cell carcinoma (mRCC) has been revolutionized by the advent of new systemic a..

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Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II) The Trans Tasman Radiation Oncology Group 13.01 Phase 2 Randomized Clinical Trial

Shankar Siva, Mathias Bressel, Tao Mai, Hien Le, Shalini Vinod, Harini de Silva, Sean Macdonald, Marketa Skala, Nicholas Hardcastle, Angela Rezo, David Pryor, Suki Gill, Braden Higgs, Kassandra Wagenfuehr, Rebecca Montgomery, Raef Awad, Brent Chesson, Thomas Eade, Wenchang Wong, Giuseppe Sasso

2021-10-01

IMPORTANCE: Evidence is lacking from randomized clinical trials to guide the optimal approach for stereotactic ablative body radio..

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Long-term Survival with 18-Fluorodeoxyglucose Positron Emission Tomography-directed Therapy in Non-small Cell Lung Cancer with Synchronous Solitary Brain Metastasis

S Newman, N Bucknell, M Bressel, P Tran, BA Campbell, S David, N Haghighi, GG Hanna, D Kok, M MacManus, C Phillips, N Plumridge, M Shaw, A Wirth, G Wheeler, D Ball, S Siva

2021-02-03

AIMS: At diagnosis, <1% of patients with non-small cell lung cancer (NSCLC) have synchronous solitary brain metastasis (SSBM). In ..

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Expanding the role of small-molecule PSMA ligands beyond PET staging of prostate cancer

Shankar Siva, Cristian Udovicich, Ben Tran, Homi Zargar, Declan G Murphy, Michael S Hofman

2020-01-14

Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is rapidly being established as arguably the leading ..

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Systematic endobronchial ultrasound-guided transbronchial needle aspiration improves radiotherapy planning in non-small cell lung cancer

Aidan Joseph Cole, Nicholas Hardcastle, Guy-Anne Turgeon, Roshini Thomas, Louis B Irving, Barton R Jennings, David Ball, Tomas Kron, Daniel P Steinfort, Shankar Siva

2019-07-01

Objectives: Patients suitable for radical chemoradiotherapy for lung cancer routinely have radiotherapy (planning) volumes based o..

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Functional lung imaging in radiation therapy for lung cancer: A systematic review and meta-analysis

Nicholas W Bucknell, Nicholas Hardcastle, Mathias Bressel, Michael S Hofman, Tomas Kron, David Ball, Shankar Siva

2018-11-01

RATIONALE: Advanced imaging techniques allow functional information to be derived and integrated into treatment planning. METHODS:..