UNDERSTANDING, REDUCING AND PREVENTING COMMUNICABLE DISEASES USING APPLIED PATHOGEN GENOMICS
Grant number: 1123854 | Funding period: 2017 - 2020
Infectious diseases are a major threat to human health. New molecular methods, particularly whole genome sequencing, promise a revolution in the way in which infections are diagnosed, detected and tracked in the 21st century. This research will use cutting edge molecular technologies to understand the factors that lead to the emergence, evolution and spread of important bacteria, including bacteria that are resistant to antibiotics.
Related publications (26)
Cost of whole genome sequencing for non-typhoidal Salmonella enterica.
Laura Ford, Kathryn Glass, Deborah A Williamson, Vitali Sintchenko, Jennifer MB Robson, Emily Lancsar, Russell Stafford, Martyn D Kirk
BACKGROUND: While whole genome sequencing (WGS) may be more expensive than traditional testing and polymerase chain reaction (PCR)..
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
Kevin C Ma, Tatum D Mortimer, Allison L Hicks, Nicole E Wheeler, Leonor Sanchez-Buso, Daniel Golparian, George Taiaroa, Daniel HF Rubin, Yi Wang, Deborah A Williamson, Magnus Unemo, Simon R Harris, Yonatan H Grad
Neisseria gonorrhoeae is an urgent public health threat due to rapidly increasing incidence and antibiotic resistance. In contrast..
Performance of the ResistancePlus MG diagnostic test for Mycoplasma genitalium using samples collected with Hologic Aptima Specimen Collection kits
Gerald L Murray, Jennifer Danielewski, Catriona S Bradshaw, Deborah A Williamson, Joshua Birnie, Jenny P Su, Vesna De Petra, Lit Y Tan, Rachel Wee, Dorothy A Machalek, Tim RH Read, Suzanne M Garland
Introduction. Mycoplasma genitalium is a sexually transmitted organism with high levels of resistance to the recommended first..
Co-circulation of Multidrug-resistant Shigella Among Men Who Have Sex With Men in Australia
Danielle J Ingle, Marion Easton, Mary Valcanis, Torsten Seemann, Jason C Kwong, Nicola Stephens, Glen P Carter, Anders Goncalves da Silva, James Adamopoulos, Sarah L Baines, Kathryn E Holt, Eric PF Chow, Christopher K Fairley, Marcus Y Chen, Martyn D Kirk, Benjamin P Howden, Deborah A Williamson
Background: In urban Australia, the burden of shigellosis is either in returning travellers from shigellosis-endemic regions, or i..
Kissing may be an important and neglected risk factor for oropharyngeal gonorrhoea: a cross-sectional study in men who have sex with men
Eric PF Chow, Vincent J Cornelisse, Deborah A Williamson, David Priest, Jane S Hocking, Catriona S Bradshaw, Tim RH Read, Marcus Y Chen, Benjamin P Howden, Christopher K Fairley
OBJECTIVES: A mathematical model suggested that a significant proportion of oropharyngeal gonorrhoea cases are acquired via oropha..
International travel as risk factor for Chlamydia trachomatis infections among young heterosexuals attending a sexual health clinic in Melbourne, Australia, 2007 to 2017
Ei T Aung, Eric PF Chow, Christopher K Fairley, Jane S Hocking, Catriona S Bradshaw, Deborah A Williamson, Marcus Y Chen
Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era
Deborah A Williamson, Eric PF Chow, Claire L Gorrie, Torsten Seemann, Danielle J Ingle, Nasra Higgins, Marion Easton, George Taiaroa, Yonatan H Grad, Jason C Kwong, Christopher K Fairley, Marcus Y Chen, Benjamin P Howden
Evidence for a new paradigm of gonorrhoea transmission: cross-sectional analysis of Neisseria gonorrhoeae infections by anatomical site in both partners in 60 male couples
Vincent Jasper Cornelisse, Deborah Williamson, Lei Zhang, Marcus Y Chen, Catriona Bradshaw, Jane S Hocking, Jennifer Hoy, Benjamin P Howden, Eric PF Chow, Christopher K Fairley
OBJECTIVE: Gonorrhoea transmission between men is currently thought to occur primarily to and from the urethra. Transmission witho..
Genomics for Molecular Epidemiology and Detecting Transmission of Carbapenemase-Producing Enterobacterales in Victoria, Australia, 2012 to 2016
Norelle L Sherry, Courtney R Lane, Jason C Kwong, Mark Schultz, Michelle Sait, Kerrie Stevens, Susan Ballard, Anders Goncalves da Silva, Torsten Seemann, Claire L Gorrie, Timothy P Stinear, Deborah A Williamson, Judith Brett, Annaliese van Diemen, Marion Easton, Benjamin P Howden
Background Carbapenemase-producing Enterobacterales (CPE) are being increasingly reported in Australia, and i..
Prevalence of genital and oropharyngeal chlamydia and gonorrhoea among female sex workers in Melbourne, Australia, 2015-2017: need for oropharyngeal testing
Eric PF Chow, Deborah A Williamson, Ria Fortune, Catriona S Bradshaw, Marcus Y Chen, Glenda Fehler, Vesna De Petra, Benjamin P Howden, Christopher K Fairley
OBJECTIVE: The Victorian legislation requires sex workers to have quarterly screening for genital chlamydia and gonorrhoea, but sc..
Risk Factors for Asymptomatic Enteric Pathogen Detection Among Men Who Have Sex With Men
Deborah A Williamson, Eric PF Chow, Darren Lee, Kate Maddaford, Michelle Sait, Marion Easton, Danielle Ingle, Rebecca Wigan, Vesna De Petra, Benjamin P Howden, Christopher K Fairley, Marcus Y Chen
<jats:title>Abstract</jats:title> <jats:p>Improved knowledge of factors that promote outbreaks of enteric pathogens..
Whole-Genome Sequencing of Salmonella Mississippi and Typhimurium Definitive Type 160 Australia and New Zealand
Laura Ford, Danielle Ingle, Kathryn Glass, Mark Veitch, Deborah A Williamson, Michelle Harlock, Joy Gregory, Russell Stafford, Nigel French, Samuel Bloomfield, Zoe Grange, Mary Lou Conway, Martyn D Kirk
Genomic Analysis of Multiresistant Staphylococcus capitis Associated with Neonatal Sepsis
Glen P Carter, James E Ussher, Anders Gonsalves Da Silva, Sarah L Baines, Helen Heffernan, Thomas Riley, Roland Broadbent, Antje van der Linden, Jean Lee, Ian R Monk, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand
Robyn S Lee, Torsten Seemann, Helen Heffernan, Jason C Kwong, Anders Goncalves da Silva, Glen P Carter, Rosemary Woodhouse, Kristin H Dyet, Dieter M Bulach, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson
Topical Antibiotic Use Coselects for the Carriage of Mobile Genetic Elements Conferring Resistance to Unrelated Antimicrobials in Staphylococcus aureus
Glen P Carter, Mark B Schultz, Sarah L Baines, Anders Goncalves da Silva, Helen Heffernan, Audrey Tiong, Peter H Pham, Ian R Monk, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson
Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns.
Deborah A Williamson, Glen P Carter, Benjamin P Howden
Bacterial skin infections represent some of the most common infectious diseases globally. Prevention and treatment of skin infecti..
Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA
Enrique Zozaya-Valdes, Jessica L Porter, John Coventry, Janet AM Fyfe, Glen P Carter, Anders Goncalves da Silva, Mark B Schultz, Torsten Seemann, Paul DR Johnson, Andrew J Stewardson, Ivan Bastian, Sally A Roberts, Benjamin P Howden, Deborah A Williamson, Timothy P Stinear
A phylogenomic framework for assessing the global emergence and evolution of clonal complex 398 methicillin-resistant Staphylococcus aureus
Anders Goncalves da Silva, Sarah L Baines, Glen P Carter, Helen Heffernan, Nigel P French, Xiaoyun Ren, Torsten Seemann, Dieter Bulach, Jason Kwong, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson