CENTRE FOR RESEARCH EXCELLENCE IN TOTAL JOINT REPLACEMENT OPTIMISING OUTCOMES, EQUITY, COST EFFECTIVENESS AND PATIENT SELECTION (OPUS)
Grant number: 1116325 | Funding period: 2016 - 2022
Joint replacement surgery is one of the most successful surgeries performed in Australia and globally. With an ageing population, demand for this procedure will increase dramatically, placing burden on a constrained health system. This Centre targets the journey of patients undergoing joint replacement surgery, seeking to optimise patient safety and outcomes, in addition to improving efficiencies and equitablity of this important surgical procedure.
Related publications (44)
Developing and internally validating a prediction model for total knee replacement surgery in patients with osteoarthritis.
Sharmala Thuraisingam, Patty Chondros, Jo-Anne Manski-Nankervis, Tim Spelman, Peter F Choong, Jane Gunn, Michelle M Dowsey
OBJECTIVE: The objective of this study was to develop and internally validate a clinical algorithm for use in general practice tha..
The role of digital health interventions to improve health literacy in surgical patients: a narrative review in arthroplasty
Myles T Davaris, Samantha Bunzli, Jason Trieu, Michelle M Dowsey, Peter F Choong
BACKGROUND: Arthroplasty is a high-volume but costly treatment option for advanced osteoarthritis. Health literacy and patient edu..
Cost-effectiveness of home-based care of febrile neutropenia in children with cancer
Michelle Tew, Richard De Abreu Lourenco, Joshua Robert Gordon, Karin A Thursky, Monica A Slavin, Franz A Babl, Lisa Orme, Penelope A Bryant, Benjamin W Teh, Kim Dalziel, Gabrielle M Haeusler
INTRODUCTION: Home-based treatment of febrile neutropenia (FN) in children with cancer with oral or intravenous antibiotics is saf..
What influences patient satisfaction after total knee replacement? A qualitative long-term follow-up study
Nardia-Rose Klem, Anne Smith, Peter O'Sullivan, Michelle M Dowsey, Robert Schutze, Peter Kent, Peter FM Choong, Samantha Bunzli
OBJECTIVES: To explore whether a conceptual model of patient satisfaction previously developed 1-2 years post-total knee replaceme..
Assessing the suitability of general practice electronic health records for clinical prediction model development: a data quality assessment
Sharmala Thuraisingam, Patty Chondros, Michelle M Dowsey, Tim Spelman, Stephanie Garies, Peter F Choong, Jane Gunn, Jo-Anne Manski-Nankervis
BACKGROUND: The use of general practice electronic health records (EHRs) for research purposes is in its infancy in Australia. Giv..
Gamifying health literacy: how can digital technology optimize patient outcomes in surgery?
Myles T Davaris, Samantha Bunzli, Michelle M Dowsey, Peter F Choong
The digital age is entrenched in our society, with constant innovation driving change in the way clinicians and patients manage th..
Cohort profile: the St Vincent's Melbourne Arthroplasty Outcomes (SMART) Registry, a pragmatic prospective database defining outcomes in total hip and knee replacement patients
Daniel Gould, Sharmala Thuraisingam, Cade Shadbolt, Josh Knight, Jesse Young, Chris Schilling, Peter F Choong, Michelle M Dowsey
PURPOSE: The St Vincent's Melbourne Arthroplasty Outcomes (SMART) Registry is an institutional clinical registry housed at a terti..
Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort
Michelle Tew, Kim Dalziel, Karin Thursky, Murray Krahn, Lusine Abrahamyan, Andrew M Morris, Philip Clarke
BACKGROUND: Cancer patients are at significant risk of developing sepsis due to underlying malignancy and necessary treatments. Li..
Developing prediction models for total knee replacement surgery in patients with osteoarthritis: Statistical analysis plan
Sharmala Thuraisingam, Michelle Dowsey, Jo-Anne Manski-Nankervis, Tim Spelman, Peter Choong, Jane Gunn, Patty Chondros
Background Approximately 12–20% of those with osteoarthritis (OA) in Australia who undergo total knee replacement (TKR) surgery do..
Risk Factors for Chronic Opioid Use Following Hip and Knee Arthroplasty: Evidence from New Zealand Population Data
Yana Pryymachenko, Ross A Wilson, J Haxby Abbott, Michelle M Dowsey, Peter FM Choong
BACKGROUND: Patients awaiting total joint arthroplasty (TJA) have high rates of opioid use, and many continue to use opioid medica..
Embedding consumer and community involvement within an established research centre: moving from general recommendations to an actionable framework
T Gunatillake, C Shadbolt, D Gould, M Lam, MG Hearst, C Vleeskens, P Choong, M Dowsey
Background: The value of involving consumers and community members in every stage of the research process is gaining recognition a..
Patient-Reported Outcomes Following Total Knee Replacement in Patients < 65 Years of Age-A Systematic Review and Meta-Analysis
Jason Trieu, Daniel J Gould, Chris Schilling, Tim Spelman, Michelle M Dowsey, Peter F Choong
An increasing number of total knee replacements (TKRs) are being performed in response to the growing burden of osteoarthritis. Pa..
National osteoarthritis strategy brief report Advanced care
Xia Wang, David J Hunter, Michelle Dowsey, Ian Harris, Peter O'Sullivan, Bill Donnelly, Thomas Buttel, Anita Wluka, Philip Clark, Raj Anand, Yuen Leow, Jane M Gunn, Yingyu Feng, Peter Choong
BACKGROUND: Osteoarthritis (OA) is one of the most common chronic joint diseases and a leading cause of pain and disability in Aus..
What Influences Patient Satisfaction after TKA? A Qualitative Investigation
Nardia-Rose Klem, Anne Smith, Peter O'Sullivan, Michelle M Dowsey, Robert Schutze, Peter Kent, Peter F Choong, Samantha Bunzli
BACKGROUND: Patient satisfaction is a common measure of the success of an orthopaedic intervention. However, there is poor underst..
Population growth, ageing and obesity do not sufficiently explain the increased utilization of total knee replacement in Australia
Jason Trieu, Michelle M Dowsey, Chris Schilling, Tim Spelman, Peter F Choong
BACKGROUND: The utilization of total knee replacement (TKR) has increased significantly. The objective of this study was to assess..
Patient-reported outcome measures (PROMs): can they be used to guide patient-centered care and optimize outcomes in total knee replacement?
Michelle Tew, Kim Dalziel, Philip Clarke, Anne Smith, Peter F Choong, Michelle Dowsey
PURPOSE: As patient-reported outcome measures (PROMs) are increasingly integrated into clinical practice, there is a need to trans..
Misconceived expectations: Patient reflections on the total knee replacement journey
Samantha Bunzli, Penny O'Brien, Nardia Klem, Ian Incoll, Jasvinder Singh, Myles Davaris, Peter Choong, Michelle Dowsey
INTRODUCTION: Fifty per cent of patients consent for total knee replacement (TKR) with unrealistic expectations about what it invo..
Exploring the Impact of Quality of Life on Survival: A Case Study in Total Knee Replacement Surgery
Michelle Tew, Kim Dalziel, Michelle Dowsey, Peter F Choong, Philip Clarke
Background. There is growing evidence that quality of life (QoL) has a strong association with mortality. However, incorporation o..
In pursuit of enhanced recovery after total joint replacement: a narrative review of drivers of length of stay
Siddharth Rele, Michelle M Dowsey, Peter FM Choong
A continual increase in the prevalence of osteoarthritis drives growing demand for total joint arthroplasty. So far, a decrease in..
Satisfaction after total knee replacement for osteoarthritis is usually high, but what are we measuring? A systematic review
Nardia-Rose Klem, Peter Kent, Anne Smith, Michelle Dowsey, Robyn Fary, Rob Schütze, Peter O'Sullivan, Peter Choong, Samantha Bunzli
Objective: Patient satisfaction is considered an important outcome measure after total knee replacement, but the construct is comp..
The Surgeon's Role in the Opioid Crisis: A Narrative Review and Call to Action
Cade Shadbolt, J Haxby Abbott, Ximena Camacho, Philip Clarke, L Stefan Lohmander, Tim Spelman, Eric C Sun, Jonas B Thorlund, Yuting Zhang, Michelle M Dowsey, Peter FM Choong
Over the past two decades, there has been a sharp rise in the use of prescription opioids. In several countries, most notably the ..
Patient-related risk factors for unplanned 30-day readmission following total knee arthroplasty: a narrative literature review
Daniel Gould, Michelle Dowsey, Imkyeong Jo, Peter Choong
Osteoarthritis is a debilitating condition as well as a growing global health problem, and total knee arthroplasty (TKA) is an eff..
Co-Morbidities and Sex Differences in Long-Term Quality-of-Life Outcomes among Patients with and without Diabetes after Total Knee Replacement: Five-Year Data from Registry Study
Michelle Tew, Michelle M Dowsey, Annabelle Choong, Peter F Choong, Philip Clarke
Improved understanding of quality-of-life (QoL) outcomes can provide valuable information on intervention effectiveness and guide ..
Long-term opioid medication use before and after joint replacement surgery in New Zealand
Ross Wilson, Yana Pryymachenko, Richard Audas, J Haxby Abbott, Peter Choong, Michelle Dowsey
AIM: To describe the use of opioid analgesics over three years before and after total joint replacement surgery in New Zealand. ME..
Opioid use prior to elective surgery is strongly associated with persistent use following surgery: an analysis of 14 354 Medicare patients
Max Catchpool, Josh Knight, Jesse T Young, Philip Clarke, Michael J Barrington, Peter FM Choong, Michelle M Dowsey
BACKGROUND: Persistent opioid use following total joint replacement (TJR) surgery is common; however, the association between pre-..
What are the patient factors that impact on decisions to progress to total knee replacement? A qualitative study involving patients with knee osteoarthritis
Penny O'Brien, Samantha Bunzli, Darshini Ayton, Michelle M Dowsey, Jane Gunn, Jo-Anne Manski-Nankervis
OBJECTIVES: General practitioners (GPs) are often the first health professionals to assess patients with osteoarthritis (OA). Desp..
Patient-related risk factors for unplanned 30-day readmission following total knee arthroplasty: a protocol for a systematic review and meta-analysis
Daniel Gould, Michelle Dowsey, Tim Spelman, Imkyeong Jo, Wassif Kabir, Jason Trieu, Peter Choong
BACKGROUND: Osteoarthritis is a debilitating condition as well as a growing global health problem, and total knee arthroplasty is ..
Knee Arthroplasty Component Malrotation Does Not Affect Function or Quality of Life in the Short to Medium Term
Sina Babazadeh, Michelle M Dowsey, Michael G Vasimalla, James D Stoney, Peter FM Choong
BACKGROUND: Component rotation in total knee arthroplasty is thought to affect patella tracking, flexion gap, and balancing and he..
Physical activity levels after hip and knee joint replacement surgery: an observational study
Lyndon J Hawke, Nora Shields, Michelle M Dowsey, Peter FM Choong, Nicholas F Taylor
Usual care after hip or knee joint replacement does not adequately address the problem of low physical activity levels. We aimed t..
National cost savings from an ambulatory program for low-risk febrile neutropenia patients in Australia
Michelle Tew, Daniel Forster, Benjamin W Teh, Kim Dalziel
Objective The management of low-risk febrile neutropenia (FN) patients through ambulatory programs has demonstrated comparative sa..
Body Mass Index Is Associated With All-cause Mortality After THA and TKA
Michelle M Dowsey, Peter FM Choong, Elizabeth W Paxton, Tim Spelman, Robert S Namba, Maria CS Inacio
BACKGROUND: Both obesity and underweight are associated with a higher risk of mortality in adulthood, but the association between ..
THE IMPACT OF ADVANCED AGE ON THE OUTCOMES OF PRIMARY TOTAL HIP AND KNEE ARTHROPLASTY FOR OSTEOARTHRITIS A Systematic Review
Benjamin P d'S Murphy, Michelle M Dowsey, Peter FM Choong
BACKGROUND: Elective total hip arthroplasty (THA) and total knee arthroplasty (TKA) are effective options for the management of os..
Gap Balancing Sacrifices Joint-Line Maintenance to Improve Gap Symmetry: 5-Year Follow-Up of a Randomized Controlled Trial
Sina Babazadeh, Michelle M Dowsey, Michael G Vasimalla, James D Stoney, Peter FM Choong
BACKGROUND: Gap balancing (GB) has been noted to sacrifice joint-line maintenance to improve gap symmetry. This study aims to dete..