DEPRESSION AND ANXIETY NEUROSCIENCE

Neurovegetative symptom subtypes in young people with major depressive disorder and their structural brain correlates

Yara Toenders, Lianne Schmaal, Ben J Harrison, Richard Dinga, Michael Berk, Christopher G Davey

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Depression is a leading cause of burden of d..

Neural mediators of subjective and autonomic responding during threat learning and regulation

Hannah S Savage, Christopher G Davey, Tor D Wager, Sarah N Garfinkel, Bradford A Moffat, Rebecca K Glarin, Ben J Harrison

2021-12-15

Threat learning elicits robust changes across multiple affective domains, including changes in autonomic indices and subjective re..

Rostral anterior cingulate network effective connectivity in depressed adolescents and associations with treatment response in a randomized controlled trial

Alec J Jamieson, Ben J Harrison, Adeel Razi, Christopher G Davey

2021-11-15

The rostral anterior cingulate cortex (rACC) is consistently implicated in the neurobiology of depression. While the functional co..

Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium

Nooshin Javaheripour, Meng Li, Tara Chand, Axel Krug, Tilo Kircher, Udo Dannlowski, Igor Nenadic, J Paul Hamilton, Matthew D Sacchet, Ian H Gotlib, Henrik Walter, Thomas Frodl, Simone Grimm, Ben J Harrison, Christian Robert Wolf, Sebastian Olbrich, Guido van Wingen, Lukas Pezawas, Gordon Parker, Matthew P Hyett

2021-10-07

Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be measured by assessing functional connectiv..

Safety learning and the Pavlovian conditioned inhibition of fear in humans: Current state and future directions.

Patrick AF Laing, Ben J Harrison

2021-08-01

Safety learning occurs when an otherwise neutral stimulus comes to signal the absence of threat, allowing organisms to use safety ..

Characterizing human safety learning via Pavlovian conditioned inhibition

Patrick AF Laing, Bram Vervliet, Miquel Angel Fullana, Hannah S Savage, Christopher G Davey, Kim L Felmingham, Ben J Harrison

2021-02-01

Deficient safety learning has been implicated in the pathogenesis of anxiety disorders. Despite increased translational interest, ..

Dynamic Neural Interactions Supporting the Cognitive Reappraisal of Emotion

Trevor Steward, Christopher G Davey, Alec J Jamieson, Katerina Stephanou, Carles Soriano-Mas, Kim L Felmingham, Ben J Harrison

2021-02-01

The cognitive reappraisal of emotion is hypothesized to involve frontal regions modulating the activity of subcortical regions suc..

Feelings of shame and guilt are associated with distinct neural activation in youth

Coralie Bastin, Divyangana Rakesh, Ben J Harrison, Christopher G Davey, Nicholas B Allen, Sandrine Muller, Sarah Whittle

2021-02-01

Shame and guilt are moral emotions that play an important role in social functioning. There is limited knowledge about the neural ..

Self-other referential neural processing in social anxiety disorder and major depressive disorder

Laura Finlayson-Short, Ben J Harrison, Christopher Davey

2021-01-01

BACKGROUND: Social anxiety disorder (SAD) and major depressive disorder (MDD) are highly comorbid and share impairments in self-re..

Threat and safety reversal learning in social anxiety disorder - an fMRI study

Hannah S Savage, Christopher G Davey, Miguel A Fullana, Ben J Harrison

2020-12-01

Social anxiety disorder (SAD) has been linked to maladaptive forms of fear regulation, including flexibly distinguishing between l..

Neural correlates of integrated self and social processing

Laura Finlayson-Short, Christopher G Davey, Ben J Harrison

2020-09-01

Self-referential and social processing are often engaged concurrently in naturalistic judgements and elicit activity in overlappin..

Neural signatures of conditioning, extinction learning, and extinction recall in posttraumatic stress disorder: a meta-analysis of functional magnetic resonance imaging studies

Benjamin Suarez-Jimenez, Anton Albajes-Eizagirre, Amit Lazarov, Xi Zhu, Ben J Harrison, Joaquim Radua, Yuval Neria, Miquel A Fullana

2020-07-01

BACKGROUND: Establishing neurobiological markers of posttraumatic stress disorder (PTSD) is essential to aid in diagnosis and trea..

Neurovegetative symptom subtypes in young people with major depressive disorder and their structural brain correlates

Yara J Toenders, Lianne Schmaal, Ben J Harrison, Richard Dinga, Michael Berk, Christopher G Davey

2020-04-20

Depression is a leading cause of burden of disease among young people. Current treatments are not uniformly effective, in part due..

Clarifying the neural substrates of threat and safety reversal learning in humans

Hannah S Savage, Christopher G Davey, Miquel A Fullana, Ben J Harrison

2020-02-15

Responding flexibly to sources of threat and safety is critical to the adaptive regulation of emotions, including fear. At a neura..

Human fear conditioning: From neuroscience to the clinic

MA Fullana, JE Dunsmoor, KRJ Schruers, HS Savage, DR Bach, BJ Harrison

2020-01-01

Both clinicians and neuroscientists have been long interested in the topic of fear conditioning, with recent advances in neuroscie..

Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits

Linden Parkes, Jeggan Tiego, Kevin Aquino, Leah Braganza, Samuel R Chamberlain, Leonardo F Fontenelle, Ben J Harrison, Valentina Lorenzetti, Bryan Paton, Adeel Razi, Alex Fornito, Murat Yucel

2019-11-15

Individual differences in impulsivity and compulsivity is thought to underlie vulnerability to a broad range of disorders and are ..

Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies

Yara J Toenders, Laura S van Velzen, Ivonne Z Heideman, Ben J Harrison, Christopher G Davey, Lianne Schmaal

2019-10-01

Major depressive disorder (MDD) often emerges during adolescence with detrimental effects on development as well as lifetime conse..

Common and distinct neural correlates of fear extinction and cognitive reappraisal: A meta-analysis of fMRI studies

M Pico-Perez, M Alemany-Navarro, JE Dunsmoor, J Radua, A Albajes-Eizagirre, B Vervliet, N Cardoner, O Benet, BJ Harrison, C Soriano-Mas, MA Fullana

2019-09-01

Cognitive reappraisal and fear extinction learning represent two different approaches to emotion regulation. While their respectiv..

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial

Christopher G Davey, Andrew M Chanen, Sarah E Hetrick, Sue M Cotton, Aswin Ratheesh, Guenter P Amminger, John Koutsogiannis, Mark Phelan, Edward Mullen, Ben J Harrison, Simon Rice, Alexendra G Parker, Olivia M Dean, Amber Weller, Melissa Kerr, Amelia L Quinn, Lisa Catania, Nikolaos Kazantzis, Patrick D McGarry, Michael Berk

2019-09-01

BACKGROUND: Medication is commonly used to treat youth depression, but whether medication should be added to cognitive behavioural..

An examination of orbitofrontal sulcogyral morphology in obsessive-compulsive disorder

Rebekah Delahoy, Cali F Bartholomeusz, Hugh Pemberton, Pino Alonso, Jesus Pujol, Narcis Cardoner, Jose M Menchon, Caries Soriano-Mas, Ben J Harrison

2019-04-30

Obsessive-compulsive disorder (OCD) has been consistently associated with structural and functional alteration of the orbitofronta..

Neurodevelopmental correlates of the emerging adult self

Christopher G Davey, Alex D Fornito, Jesus Pujol, Michael Breakspear, Lianne Schmaal, Ben J Harrison

2019-04-01

The self-concept - the set of beliefs that a person has about themselves - shows significant development from adolescence to early..

Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants

Miquel A Fullana, Anton Albajes-Eizagirre, Caries Soriano-Mas, Bram Vervliet, Narcis Cardoner, Olivia Benet, Joaquim Radua, Ben J Harrison

2018-05-01

The study of fear extinction represents an important example of translational neuroscience in psychiatry and promises to improve t..

Predictors and consequences of health anxiety symptoms: a novel twin modeling study

C Lopez-Sola, M Bui, JL Hopper, LF Fontenelle, CG Davey, C Pantelis, P Alonso, OA van den Heuvel, BJ Harrison

2018-03-01

OBJECTIVE: The question of how to best conceptualize health anxiety (HA) from a diagnostic and etiological perspective remains deb..

A Brain Model of Disturbed Self-Appraisal in Depression

Christopher G Davey, Michael Breakspear, Jesus Pujol, Ben J Harrison

2017-09-01

OBJECTIVE: A disturbed sense of self is a core feature of depression. The medial prefrontal cortex, which has a central role in se..

Hard to look on the bright side: neural correlates of impaired emotion regulation in depressed youth

Katerina Stephanou, Christopher G Davey, Rebecca Kerestes, Sarah Whittle, Ben J Harrison

2017-07-01

The cognitive regulation of emotion is impaired in major depressive disorder and has been linked to an imbalance of pre-frontal-su..

Human ventromedial prefrontal cortex and the positive affective processing of safety signals

Ben J Harrison, Miguel Angel Fullana, Esther Via, Carles Soriano-Mas, Bram Vervliet, Ignacio Martinez-Zalacain, Jesus Pujol, Christopher G Davey, Tilo Kircher, Benjamin Straube, Narcis Cardoner

2017-05-15

Human functional magnetic resonance imaging (fMRI) studies suggest that the ventromedial prefrontal cortex (vmPFC) contributes to ..