NEURODEVELOPMENTAL RISK FACTORS FOR DEPRESSION FROM CHILDHOOD TO EARLY ADULTHOOD
Grant number: 1125504 | Funding period: 2017 - 2021
To understand who is at risk for depression, we need to understand how both the environment and biological factors promote risk at specific times in the life cycle. This research project will examine such risk factors in different phases of life (from in utero to early adulthood) using a developmental framework. The results of this research will provide a clearer basis for the design of prevention strategies that target individuals, their families and/or broader environmental factors.
Related publications (28)
A longitudinal analysis of puberty-related cortical development
Nandita Vijayakumar, George Youssef, Nicholas B Allen, Vicki Anderson, Daryl Efron, Philip Hazell, Lisa Mundy, Jan M Nicholson, George Patton, Marc L Seal, Julian G Simmons, Sarah Whittle, Tim Silk
<jats:title>Abstract</jats:title><jats:p>The brain undergoes extensive structural changes during adolescence, concurrent to pubert..
Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence
Divyangana Rakesh, Vanessa Cropley, Andrew Zalesky, Nandita Vijayakumar, Nicholas B Allen, Sarah Whittle
Neighborhood disadvantage has consistently been linked to alterations in brain structure; however, positive environmental (e.g., p..
Similar but distinct - Effects of different socioeconomic indicators on resting state functional connectivity: Findings from the Adolescent Brain Cognitive Development (ABCD) Study
Divyangana Rakesh, Andrew Zalesky, Sarah Whittle
Early socioeconomic status (SES) has consistently been associated with child health and cognitive outcomes, in addition to alterat..
Associations Between Neighborhood Disadvantage, Resting-State Functional Connectivity, and Behavior in the Adolescent Brain Cognitive Development Study: The Moderating Role of Positive Family and School Environments
Divyangana Rakesh, Caio Seguin, Andrew Zalesky, Vanessa Cropley, Sarah Whittle
BACKGROUND: Neighborhood disadvantage has consistently been associated with mental health and cognitive function, in addition to a..
Associations between cognitive and affective empathy and internalizing symptoms in late childhood
Katherine O Bray, Vicki Anderson, Christos Pantelis, Elena Pozzi, Orli S Schwartz, Nandita Vijayakumar, Sally Richmond, Camille Deane, Nicholas B Allen, Sarah Whittle
BACKGROUND: Empathy is a multidimensional construct, which includes cognitive and affective components. Studies in adults have dem..
A Researcher's Guide to the Measurement and Modeling of Puberty in the ABCD Study (R) at Baseline
Theresa W Cheng, Lucia Magis-Weinberg, Victoria Guazzelli Williamson, Cecile D Ladouceur, Sarah L Whittle, Megan M Herting, Kristina A Uban, Michelle L Byrne, Marjolein EA Barendse, Elizabeth A Shirtcliff, Jennifer H Pfeifer
The Adolescent Brain Cognitive Development℠ (ABCD) Study is an ongoing, diverse, longitudinal, and multi-site study of 11,880 adol..
The development of structural covariance networks during the transition from childhood to adolescence
Nandita Vijayakumar, Gareth Ball, Marc L Seal, Lisa Mundy, Sarah Whittle, Tim Silk
Structural covariance conceptualizes how morphologic properties of brain regions are related to one another (across individuals). ..
Maternal parenting behavior and functional connectivity development in children: A longitudinal fMRI study
Elena Pozzi, Nandita Vijayakumar, Michelle L Byrne, Katherine O Bray, Marc Seal, Sally Richmond, Andrew Zalesky, Sarah L Whittle
Parenting behavior is associated with internalizing symptoms in children, and cross-sectional research suggests that this associat..
A longitudinal analysis of puberty-related cortical development
Nandita Vijayakumar, George J Youssef, Nicholas B Allen, Vicki Anderson, Daryl Efron, Philip Hazell, Lisa Mundy, Jan M Nicholson, George Patton, Marc L Seal, Julian G Simmons, Sarah Whittle, Tim Silk
The brain undergoes extensive structural changes during adolescence, concurrent to puberty-related physical and hormonal changes. ..
The impact of posttraumatic stress disorder on event-related potentials in affective and non-affective paradigms: A systematic review with meta-analysis
Lisa N Miller, Julian G Simmons, Sarah Whittle, David Forbes, Kim Felmingham
Post-traumatic stress disorder (PTSD) is associated with neural processing deficits affecting early automatic and later conscious ..
Unraveling the Consequences of Childhood Maltreatment: Deviations From Typical Functional Neurodevelopment Mediate the Relationship Between Maltreatment History and Depressive Symptoms
Divyangana Rakesh, Clare Kelly, Nandita Vijayakumar, Andrew Zalesky, Nicholas B Allen, Sarah Whittle
BACKGROUND: Childhood maltreatment is associated with lifelong psychiatric sequelae. However, our understanding of neurobiological..
Feelings of shame and guilt are associated with distinct neural activation in youth
Coralie Bastin, Divyangana Rakesh, Ben J Harrison, Christopher G Davey, Nicholas B Allen, Sandrine Muller, Sarah Whittle
Shame and guilt are moral emotions that play an important role in social functioning. There is limited knowledge about the neural ..
Neural Correlates of Emotion Regulation in Adolescents and Emerging Adults: A Meta-analytic Study
Elena Pozzi, Nandita Vijayakumar, Divyangana Rakesh, Sarah Whittle
BACKGROUND: The development of adaptive implicit and explicit emotion regulation skills is crucial for mental health. Adolescence ..
Associations between early life stress and anterior pituitary gland volume development - A novel index of long-term hypothalamic-pituitary-adrenal axis functioning
Carmela Diaz-Arteche, Julian G Simmons, Despina E Ganella, Orli Schwartz, Jee Hyun Kim, Paige Farrow, Sarah Whittle
Previous research has established associations between early life stress (ELS) and altered pituitary gland volume (PGV) growth dur..
Associations between early life stress and anterior pituitary gland volume development during late childhood
Paige Farrow, Julian G Simmons, Elena Pozzi, Carmela Diaz-Arteche, Sally Richmond, Katherine Bray, Orli Schwartz, Sarah Whittle
Early Life Stress (ELS) is thought to influence Hypothalamic-Pituitary-Adrenal-Axis (HPAA) functioning, contributing to an increas..
Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?
Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate LEP Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz
BACKGROUND: Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra..
Social and affective neuroscience: an Australian perspective
Fiona Kumfor, Lincoln M Tracy, Grace Wei, Yu Chen, Juan FD Dominguez, Sarah Whittle, Travis Wearne, Michelle Kelly
While research in social and affective neuroscience has a long history, it is only in the last few decades that it has been truly ..
Common mechanisms of executive attention underlie executive function and effortful control in children
Jeggan Tiego, Mark A Bellgrove, Sarah Whittle, Christos Pantelis, Renee Testa
Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and ..
Relationships between adrenarcheal hormones, hippocampal volumes and depressive symptoms in children
Rachel Ellis, Anna Fernandes, Julian G Simmons, Lisa Mundy, George Patton, Nicholas B Allen, Sarah Whittle
Early timing of puberty (i.e., advanced pubertal maturation relative to same-age peers) has been associated with depressive sympto..
Early Adolescent Drinking and Cannabis Use Predicts Later Sleep-Quality Problems
Rowan P Ogeil, Ali Cheetham, Anna Mooney, Nicholas B Allen, Orli Schwartz, Michelle L Byrne, Julian G Simmons, Sarah Whittle, Dan Lubman
A range of biopsychosocial changes occur during adolescence that contribute to changes in the sleep-wake system. Use of alcohol an..
An fMRI study of theory of mind in individuals with first episode psychosis
Cali F Bartholomeusz, Eleni P Ganella, Sarah Whittle, Kelly Allott, Andrew Thompson, Ahmad Abu-Akerl, Henrik Walter, Patrick McGorry, Eoin Killackey, Christos Pantelis, Stephen J Wood
Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the ..
Associations between adrenarcheal hormones, amygdala functional connectivity and anxiety symptoms in children
Marjolein EA Barendse, Julian G Simmons, Michelle L Byrne, George Patton, Lisa Mundy, Craig A Olsson, Marc L Seal, Nicholas B Allen, Sarah Whittle
OBJECTIVE: The transition from childhood to adolescence is a vulnerable period for the development of anxiety symptoms. There is s..
Brain structural connectivity during adrenarche: Associations between hormone levels and white matter microstructure
Marjolein EA Barendse, Julian G Simmons, Michelle L Byrne, Marc L Seal, George Patton, Lisa Mundy, Stephen J Wood, Craig A Olsson, Nicholas B Allen, Sarah Whittle
Levels of the adrenal hormones dehydroepiandrosterone (DHEA), its sulfate (DHEAS), and testosterone, have all been linked to behav..
Extinction of Conditioned Fear in Adolescents and Adults: A Human fMRI Study
Despina E Ganella, Katherine D Drummond, Eleni P Ganella, Sarah Whittle, Jee Hyun Kim
Little is known about the neural correlates of fear learning in adolescents, a population at increased risk for anxiety disorders...