MANIPULATION OF CLATHRIN-MEDIATED TRAFFICKING BY COXIELLA
Grant number: 1120344 | Funding period: 2017 - 2019
This research will uncover how Coxiella causes the serious infectious disease Q fever by commandeering human cells and replicating to high numbers within a specialised vacuole. We will investigate virulence factors of Coxiella, learning how and why they target an essential human vesicular trafficking process. Our innovative approach and unique expertise will elucidate interaction between this pathogen and the human cell, providing fundamental knowledge towards public health outcomes.
Related publications (7)
EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii
Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton
The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..
Lysosomal degradation products induce Coxiella burnetii virulence
Patrice Newton, David R Thomas, Shawna CO Reed, Nicole Lau, Bangyan Xu, Sze Ying Ong, Shivani Pasricha, Piyush B Madhamshettiwar, Laura E Edgington-Mitchell, Kaylene J Simpson, Craig R Roy, Hayley J Newton
Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB..
Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3
Bhavna Padmanabhan, Laura F Fielden, Abderrahman Hachani, Patrice Newton, David R Thomas, Hyun-Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R Roy, Nichollas E Scott, Hayley J Newton
Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing ..
SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole
Nicole Lau, Amanda L Haeberle, Brittany J O'Keeffe, Eleanor A Latomanski, Jean Celli, Hayley J Newton, Leigh A Knodler
The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilizes two type III secretion systems (..
De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever
MA Bitew, CA Khoo, N Neha, DP De Souza, D Tull, NK Wawegama, HJ Newton, FM Sansom
© 2018 Bitew et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. Coxiell..