MICROBIOTA AND T CELL IMMUNITY
Grant number: 1124815 | Funding period: 2017 - 2019
Our research has identified unprecedented communications between the microbes that colonize our body’s surfaces and killer T cell immunity. Our findings indicate that microflora is key to a healthy balance between two immune mediator systems that have opposing effect on T cell immunity. The project will extend our understanding of how this regulated and seeks to harness these novel insights to explain the well known, but poorly understood role of microbes in autoimmune diseases.
Related publications (2)
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells
Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish
Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..
Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance
Thomas Gebhardt, Umaimainthan Palendira, David C Tscharke, Sammy Bedoui
A large proportion of memory T cells disseminated throughout the body are non-recirculating cells whose maintenance and function i..