SYTEMIC AND MUCOSAL FUNCTIONAL ANTIBODIES IN PROTECTION AGAINST HIV

Grant number: 1125164 | Funding period: 2017 - 2019

Completed

Abstract

Only one human HIV vaccine has shown any level of protective efficacy. However the mechanisms behind how this vaccine was protective are still not fully understood. Additionally, HIV is primarily transmitted through mucosal sites, however very little is know about vaccine immune responses at these sites. Thus this proposal aims to further define the mechanisms of antibody protection against HIV at both systemic and mucosal locations, in order to guide future HIV vaccine design efforts.

Related publications (8)

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A Quantitative Approach to Unravel the Role of Host Genetics in IgG-Fc gamma R Complex Formation After Vaccination

Melissa M Lemke, Robert M Theisen, Emily R Bozich, Milla R McLean, Christina Y Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, Kelly B Arnold

2022-02-22

Fc-mediated immune functions have been correlated with protection in the RV144 HIV vaccine trial and are important for immunity to..

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A systems approach to elucidate personalized mechanistic complexities of antibody-Fc receptor activation post-vaccination

Melissa M Lemke, Milla R McLean, Christina Y Lee, Ester Lopez, Emily R Bozich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, Kelly B Arnold

2021-09-23

Immunoglobulin G (IgG) antibodies that activate Fc-mediated immune functions have been correlated with vaccine efficacy, but it is..

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Serum IgA Fc effector functions in infectious disease and cancer

Samantha K Davis, Kevin J Selva, Stephen J Kent, Amy W Chung

2020-04-01

Immunoglobulin (Ig) A is the most abundant antibody isotype present at mucosal surfaces and the second most abundant in human seru..

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Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcg Receptors: Implications for Measuring Fc Dependent Antibody Functions

Ester Lopez, Nichollas E Scott, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Stephen J Kent, Amy W Chung

2019-10-11

Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and aut..

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The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV

Ester Lopez, Robin J Shattock, Stephen J Kent, Amy W Chung

2018-09-01

IgA is the most abundant immunoglobulin in mucosal secretions, and understanding the role of IgA in both protection from HIV acqui..

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Neutrophils mediate HIV-specific antibody-dependent phagocytosis and ADCC

Matthew J Worley, Kuangyu Fei, Adam J Lopez-Denman, Anthony D Kelleher, Stephen J Kent, Amy W Chung

2018-06-01

There is growing evidence to support the role of Fc-mediated effector functions, such as Antibody-Dependent Cellular cytotoxicity ..

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Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nussing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi HO Nguyen

2018-02-14

Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy to combat seasonal influenza infecti..

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A Role for Fc-Mediated Humoral Immunity in Reducing HIV Transmission Rates between HIV Serodiscordant Heterosexual Couples

Stephen J Kent, Amy W Chung

2017-12-01

University of Melbourne Researchers