NOVEL THERAPIES TARGETING THE ALTERNATE RENIN ANGIOTENSIN SYSTEM IN CHRONIC LIVER DISEASE
Grant number: 1124125 | Funding period: 2017 - 2022
Scarring of the liver due to chronic liver diseases (cirrhosis) is now a major cause of illness and death in Australia. This project will study whether drugs and gene therapy approaches targeting a hormone system called the renin angiotensin system can be used to prevent the development of cirrhosis and its complications.
Related publications (3)
Liver-Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug-Resistant Gene 2-Knockout Mice
Indu G Rajapaksha, Lakmie S Gunarathne, Khashayar Asadi, Sharon C Cunningham, Alexandra Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath
There is a large unmet need for effective therapies for cholestatic disorders, including primary sclerosing cholangitis (PSC), a d..
Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats
Lakmie S Gunarathne, Peter W Angus, Chandana B Herath
Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with ci..
The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice
Indu G Rajapaksha, Kai Y Mak, Ping Huang, Louise M Burrell, Peter W Angus, Chandana B Herath
There is no established medical therapy to treat biliary fibrosis resulting from chronic inflammation in the biliary tree. We have..