NOVEL THERAPIES TARGETING THE ALTERNATE RENIN ANGIOTENSIN SYSTEM IN CHRONIC LIVER DISEASE

Liver-Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug-Resistant Gene 2-Knockout Mice

Indu G Rajapaksha, Lakmie S Gunarathne, Khashayar Asadi, Sharon C Cunningham, Alexandra Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath

2019-12-01

There is a large unmet need for effective therapies for cholestatic disorders, including primary sclerosing cholangitis (PSC), a d..

Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats

Lakmie S Gunarathne, Peter W Angus, Chandana B Herath

2019-09-20

Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with ci..

The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice

Indu G Rajapaksha, Kai Y Mak, Ping Huang, Louise M Burrell, Peter W Angus, Chandana B Herath

2018-07-05

There is no established medical therapy to treat biliary fibrosis resulting from chronic inflammation in the biliary tree. We have..