DISSECTING VIRULENCE ATTRIBUTES IN A HUMAN PATHOGENIC FUNGUS
Grant number: 1126384 | Funding period: 2017 - 2021
Fungi that infect humans are a major health problem worldwide, particularly for those with compromised immune systems (eg. AIDS, transplant and cancer patients). These fungi cause disease by evading the immune system whilst deriving nutrients for growth. Some fungi evade the immune system by residing within host cells; a hostile and nutrient poor environment. This project will study genes that are required for growth inside host cells. This knowledge will open new avenues for treatment.
Related publications (2)
The novel Dbl homology/BAR domain protein, MsgA, of Talaromyces marneffei regulates yeast morphogenesis during growth inside host cells
Harshini Weerasinghe, Hayley E Bugeja, Alex Andrianopoulos
Microbial pathogens have evolved many strategies to evade recognition by the host immune system, including the use of phagocytic c..
A unique aspartyl protease gene expansion in Talaromyces marneffei plays a role in growth inside host phagocytes
Michael Payne, Harshini Weerasinghe, Irma Tedja, Alex Andrianopoulos
Aspartyl proteases are a widely represented class of proteolytic enzymes found in eukaryotes and retroviruses. They have been asso..