DEEPENING OUR UNDERSTANDING OF OCULAR SURFACE NEUROIMMUNOLOGY

Grant number: 1126540 | Funding period: 2017 - 2022

Completed

Abstract

It is becoming clear that the interaction between corneal nerves and immune cells underpin many inflammatory conditions of the ocular surface. Despite this increased interest, very little is known about the relationship between corneal nerves and immune cells in this outermost layer of the eye. This project will investigate the relationship between corneal nerves and immune cells during health and corneal inflammation to identify therapeutic targets to treat corneal disease.

Related publications (14)

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Topical Decorin Reduces Corneal Inflammation and Imparts Neuroprotection in a Mouse Model of Benzalkonium Chloride-induced Corneal Neuropathy.

Mengliang Wu, Laura E Downie, Lisa J Hill, Holly R Chinnery

2023-02-01

PURPOSE: We evaluated the neuroprotective and immunomodulatory effects of topical decorin in a murine model of benzalkonium chlori..

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Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

Mengliang Wu, Lisa J Hill, Laura E Downie, Holly R Chinnery

2022-11-08

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with their important roles in the mainte..

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Topographical Distribution and Phenotype of Resident Meibomian Gland Orifice Immune Cells (MOICs) in Mice and the Effects of Topical Benzalkonium Chloride (BAK)

Ching Yi Wu, Mengliang Wu, Xin Huang, Ben J Gu, Carole Maldonado-Codina, Philip B Morgan, Laura E Downie, Holly R Chinnery

2022-09-01

Meibomian gland orifices (MGOs) are located along the eyelid margin and secrete meibum into the tear film. The profile of resident..

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The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion

Mengliang Wu, Laura E Downie, Lisa J Hill, Holly R Chinnery

2022-04-12

BACKGROUND: Corneal immune cells interact with corneal sensory nerves during both homeostasis and inflammation. This study sought ..

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Corneal immune cell morphometry as an indicator of local and systemic pathology: A review

Holly R Chinnery, Xin Yuan Zhang, Ching Yi Wu, Laura E Downie

2021-07-20

The corneal epithelium contains a population of resident immune cells commonly referred to as dendritic cells (DCs), or Langerhans..

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Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury

Haihan Jiao, Jason J Ivanusic, Paul G McMenamin, Holly R Chinnery

2021-07-01

PURPOSE: Given the role of corneal sensory nerves during epithelial wound repair, we sought to examine the relationship between im..

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Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review

Holly Rose Chinnery, Rajni Rajan, Haihan Jiao, Mengliang Wu, Alexis Ceecee Zhang, Manikkuwadura Eranda Harshan De Silva, Eve Makrai, Mary Ann Stepp, Nick Di Girolamo, Laura Elizabeth Downie

2021-02-10

BACKGROUND/AIMS: This systematic review critically evaluated peer-reviewed publications describing morphological features consiste..

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Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline

Kirthana Senthil, Haihan Jiao, Laura E Downie, Holly R Chinnery

2021-02-01

Purpose: The purpose of this study was to assess the morphological and phenotypic responses of corneal epithelial dendritic cells ..

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The effect of high-fat diet-induced metabolic disturbance on corneal neuroimmune features

Haihan Jiao, Alicia SL Lim, Therese E Fazio Coles, Rachel M McQuade, John B Furness, Holly R Chinnery

2020-12-01

PURPOSE: The highly innervated cornea is susceptible to nerve loss secondary to systemic diseases such as diabetes and metabolic d..

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The neuroregenerative effects of topical decorin on the injured mouse cornea

Holly Chinnery, Mengliang Wu, Laura Elizabeth Downie, Haihan Jiao, Liam Grover, Ann Logan, Kirthana Senthil, Lisa J Hill

2020-06-01

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Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy

Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery

2020-04-28

BACKGROUND: Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alz..

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Topographical and Morphological Differences of Corneal Dendritic Cells during Steady State and Inflammation

Haihan Jiao, Cecilia Naranjo Golborne, Samantha J Dando, Paul G McMenamin, Laura E Downie, Holly R Chinnery

2019-08-19

PURPOSE: We report novel differences in mouse corneal DC morphology and density during local and systemic inflammation. METHODS: L..

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Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease

Haihan Jiao, Lisa J Hill, Laura E Downie, Holly R Chinnery

2019-05-01

Optical coherence tomography (OCT) provides non-invasive, high-resolution in vivo imaging of the ocular surface and anterior segme..

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Morphological changes to murine corneal dendritic cells after local and systemic inflammation

Holly Rose Chinnery, Samantha Dando, Paul G McMenamin, Cecilia Naranjo Golborne

2018-07-01

University of Melbourne Researchers