DEEPENING OUR UNDERSTANDING OF OCULAR SURFACE NEUROIMMUNOLOGY
Grant number: 1126540 | Funding period: 2017 - 2022
It is becoming clear that the interaction between corneal nerves and immune cells underpin many inflammatory conditions of the ocular surface. Despite this increased interest, very little is known about the relationship between corneal nerves and immune cells in this outermost layer of the eye. This project will investigate the relationship between corneal nerves and immune cells during health and corneal inflammation to identify therapeutic targets to treat corneal disease.
Related publications (8)
Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury
Haihan Jiao, Jason J Ivanusic, Paul G McMenamin, Holly R Chinnery
Purpose: Given the role of corneal sensory nerves during epithelial wound repair, we sought to examine the relationship between im..
Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.
Holly Rose Chinnery, Rajni Rajan, Haihan Jiao, Mengliang Wu, Alexis Ceecee Zhang, Manikkuwadura Eranda Harshan De Silva, Eve Makrai, Mary Ann Stepp, Nick Di Girolamo, Laura Elizabeth Downie
BACKGROUND/AIMS: This systematic review critically evaluated peer-reviewed publications describing morphological features consiste..
Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline
Kirthana Senthil, Haihan Jiao, Laura E Downie, Holly R Chinnery
Purpose: The purpose of this study was to assess the morphological and phenotypic responses of corneal epithelial dendritic cells ..
The effect of high-fat diet-induced metabolic disturbance on corneal neuroimmune features
Haihan Jiao, Alicia SL Lim, Therese E Fazio Coles, Rachel M McQuade, John B Furness, Holly R Chinnery
PURPOSE: The highly innervated cornea is susceptible to nerve loss secondary to systemic diseases such as diabetes and metabolic d..
Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy
Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery
BACKGROUND: Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alz..
Topographical and Morphological Differences of Corneal Dendritic Cells during Steady State and Inflammation
Haihan Jiao, Cecilia Naranjo Golborne, Samantha J Dando, Paul G McMenamin, Laura E Downie, Holly R Chinnery
PURPOSE: We report novel differences in mouse corneal DC morphology and density during local and systemic inflammation. METHODS: L..
Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease
Haihan Jiao, Lisa J Hill, Laura E Downie, Holly R Chinnery
Optical coherence tomography (OCT) provides non-invasive, high-resolution in vivo imaging of the ocular surface and anterior segme..