DEEPENING OUR UNDERSTANDING OF OCULAR SURFACE NEUROIMMUNOLOGY
Grant number: 1126540 | Funding period: 2017 - 2021
It is becoming clear that the interaction between corneal nerves and immune cells underpin many inflammatory conditions of the ocular surface. Despite this increased interest, very little is known about the relationship between corneal nerves and immune cells in this outermost layer of the eye. This project will investigate the relationship between corneal nerves and immune cells during health and corneal inflammation to identify therapeutic targets to treat corneal disease.
Related publications (6)
Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.
Holly Rose Chinnery, Rajni Rajan, Haihan Jiao, Mengliang Wu, Alexis Ceecee Zhang, Manikkuwadura Eranda Harshan De Silva, Eve Makrai, Mary Ann Stepp, Nick Di Girolamo, Laura Elizabeth Downie
BACKGROUND/AIMS: This systematic review critically evaluated peer-reviewed publications describing morphological features consiste..
Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline
Kirthana Senthil, Haihan Jiao, Laura E Downie, Holly R Chinnery
Purpose: The purpose of this study was to assess the morphological and phenotypic responses of corneal epithelial dendritic cells ..
The effect of high-fat diet-induced metabolic disturbance on corneal neuroimmune features
Haihan Jiao, Alicia SL Lim, Therese E Fazio Coles, Rachel M McQuade, John B Furness, Holly R Chinnery
PURPOSE: The highly innervated cornea is susceptible to nerve loss secondary to systemic diseases such as diabetes and metabolic d..
Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy
Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery
BACKGROUND: Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alz..