CLONAL EVOLUTION IN MYELODYSPLASIA AND ACUTE MYELOID LEUKAEMIA FOLLOWING AZACITIDINE

Grant number: 1128984 | Funding period: 2017 - 2020

Completed

Abstract

The myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) represent a spectrum of clinically heterogeneous malignancies that remain incurable in the vast majority of patients. Whilst the DNA mutations underpinning the initiation/maintenance of these malignancies are largely known we have little insight into how these mutations alter response to therapy. Using a range of sophisticated cutting edge technologies we will study how these DNA mutations evolve over the course of treatment.

Related publications (4)

Scholarly works icon

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

Nila J Dharan, Paul Yeh, Mark Bloch, Miriam M Yeung, David Baker, Jerick Guinto, Norman Roth, Sarah Ftouni, Katherine Ognenovska, Don Smith, Jennifer F Hoy, Ian Woolley, Catherine Pell, David J Templeton, Neil Fraser, Nectarios Rose, Jolie Hutchinson, Kathy Petoumenos, Sarah-Jane Dawson, Mark N Polizzotto

2021-06-07

People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and..

Scholarly works icon

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon

2019-10-14

Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 sc..

Scholarly works icon

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

Charles C Bell, Katie A Fenne, Yih-Chih Chan, Florian Rambow, Miriam M Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G Martelotto, Aljosja Rogiers, Brandon E Kremer, Olena Barbash, Helai P Mohammad, Timothy M Johanson, Marian L Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S Tyler, Laura MacPherson

2019-06-20

Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it..

Scholarly works icon

Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

Paul Yeh, Michael Dickinson, Sarah Ftouni, Tane Hunter, Devbarna Sinha, Stephen Q Wong, Rishu Agarwal, Ravikiran Vedururu, Kenneth Doig, Chun Yew Fong, Piers Blombery, David Westerman, Mark A Dawson, Sarah-Jane Dawson

2017-03-23

The diagnosis and monitoring of myelodysplastic syndromes (MDSs) are highly reliant on bone marrow morphology, which is associated..

University of Melbourne Researchers