CRITICAL SLOWING IN EPILEPSY

Grant number: 1130468 | Funding period: 2017 - 2019

Completed

Abstract

Seizures appear unpredictable and greatly affect the quality of all aspects of life for patients with epilepsy and their carers. New advances in complex systems theory suggest that transitions from normal brain activity to seizures are preceded by measurable changes in the brain’s responses to stimuli, known as critical slowing. Measurement of critical slowing will enable prediction of seizures, providing a warning system, and possibly an opportunity to deliver preventative therapies.

Related publications (4)

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Critical slowing down as a biomarker for seizure susceptibility.

Matias I Maturana, Christian Meisel, Katrina Dell, Philippa J Karoly, Wendyl D'Souza, David B Grayden, Anthony N Burkitt, Premysl Jiruska, Jan Kudlacek, Jaroslav Hlinka, Mark J Cook, Levin Kuhlmann, Dean R Freestone

2020-05-01

The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in lo..

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Forecasting cycles of seizure likelihood

Philippa J Karoly, Mark J Cook, Matias Maturana, Ewan S Nurse, Daniel Payne, Benjamin H Brinkmann, David B Grayden, Sonya B Dumanis, Mark P Richardson, Greg A Worrell, Andreas Schulze-Bonhage, Levin Kuhlmann, Dean R Freestone

2020-03-27

Objective Seizure unpredictability is rated as one of the most challenging aspects of living with epilepsy. Seizure likelihood can..

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Convolutional neural networks for seizure prediction using intracranial and scalp electroencephalogram

Duy Truong Nhan, Duy Nguyen Anh, Levin Kuhlmann, Mohammad Reza Bonyadi, Jiawei Yang, Samuel Ippolito, Omid Kavehei

2018-09-01

Seizure prediction has attracted growing attention as one of the most challenging predictive data analysis efforts to improve the ..

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Epilepsyecosystem.org: crowd-sourcing reproducible seizure prediction with long-term human intracranial EEG

Levin Kuhlmann, Philippa Karoly, Dean R Freestone, Benjamin H Brinkmann, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Scott Dobson, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg

2018-09-01

Accurate seizure prediction will transform epilepsy management by offering warnings to patients or triggering interventions. Howev..