CHARACTERIZATION OF THE TYPE IX SECRETION SYSTEM IN PORPHYROMONAS GINGIVALIS
Grant number: 1123866 | Funding period: 2017 - 2020
Periodontitis is associated with the keystone pathogen Porphyromonas gingivalis. We have identified a novel protein secretion machine comprised of at least 12 components in P. gingivalis which transports the bacterium's major virulence factors to the cell surface and attaches them to the outer membrane. We aim to determine the spatial arrangement and specific role of each of these 12 components and thereby provide targets for future treatments against this disease.
Related publications (6)
Complementation in trans of Porphyromonas gingivalis Lipopolysaccharide Biosynthetic Mutants Demonstrates Lipopolysaccharide Exchange
Michelle D Glew, Dhana G Gorasia, Paul J McMillan, Catherine A Butler, Paul D Veith, Eric C Reynolds
Porphyromonas gingivalis, a bacterial pathogen contributing to human periodontitis, exports and anchors cargo proteins to its surf..
Type IX Secretion System Cargo Proteins Are Glycosylated at the C Terminus with a Novel Linking Sugar of the Wbp/Vim Pathway
Paul D Veith, Mikio Shoji, Richard AJ O'Hair, Michael G Leeming, Shuai Nie, Michelle D Glew, Gavin E Reid, Koji Nakayama, Eric C Reynolds
Porphyromonas gingivalis and Tannerella forsythia use the type IX secretion system to secrete cargo proteins to the cell surface w..
Quantitative proteomic analysis of the type IX secretion system mutants in Porphyromonas gingivalis
Dhana G Gorasia, Michelle D Glew, Paul D Veith, Eric C Reynolds
Porphyromonas gingivalis is an anaerobic, gram-negative human oral pathogen highly associated with chronic periodontitis. P. gingi..