MECHANISMS OF B CELL IMMUNODOMINANCE TO INFLUENZA VIRUS

Grant number: 1129099 | Funding period: 2017 - 2019

Completed

Abstract

Current influenza vaccines elicit poor protection against viruses undergoing rapid change or emerging from animal reservoirs. We will define the basis for why highly conserved sites of virus vulnerability, such as the hemagglutinin "stem" domain, are poorly targeted by current vaccines and will assess novel hemagglutinin stem-based vaccines in macaque models of human influenza. Our results will guide the rational design of next-generation vaccines for influenza.

Related publications (7)

University of Melbourne Researchers