MECHANISMS OF B CELL IMMUNODOMINANCE TO INFLUENZA VIRUS

Grant number: 1129099 | Funding period: 2017 - 2019

Completed

Abstract

Current influenza vaccines elicit poor protection against viruses undergoing rapid change or emerging from animal reservoirs. We will define the basis for why highly conserved sites of virus vulnerability, such as the hemagglutinin "stem" domain, are poorly targeted by current vaccines and will assess novel hemagglutinin stem-based vaccines in macaque models of human influenza. Our results will guide the rational design of next-generation vaccines for influenza.

Related publications (7)

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Sequencing B cell receptors from ferrets (Mustela putorius furo)

Julius Wong, Celeste M Tai, Aeron C Hurt, Hyon-Xhi Tan, Stephen J Kent, Adam K Wheatley

2020-05-29

The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunolo..

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Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

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Improving immunological insights into the ferret model of human viral infectious disease

Julius Wong, Daniel Layton, Adam K Wheatley, Stephen J Kent

2019-10-03

Ferrets are a well-established model for studying both the pathogenesis and transmission of human respiratory viruses and evaluati..

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Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice

Hyon-Xhi Tan, Robyn Esterbauer, Hillary A Vanderven, Jennifer A Juno, Stephen J Kent, Adam K Wheatley

2019-03-29

Seasonally recurrent influenza virus infections are a significant cause of global morbidity and mortality. In murine models, prima..

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Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Hyon-Xhi Tan, Sinthujan Jegaskanda, Jennifer A Juno, Robyn Esterbauer, Julius Wong, Hannah G Kelly, Yi Liu, Danielle Tilmanis, Aeron C Hurt, Jonathan W Yewdell, Stephen J Kent, Adam K Wheatley

2019-02-01

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against ..

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Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

Yi Liu, Hyon-Xhi Tan, Marios Koutsakos, Sinthujan Jegaskanda, Robyn Esterbauer, Danielle Tilmanis, Malet Aban, Katherine Kedzierska, Aeron C Hurt, Stephen J Kent, Adam K Wheatley

2019-01-18

Influenza B viruses (IBV) drive a significant proportion of influenza-related hospitalisations yet are understudied compared to in..

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Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nussing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi HO Nguyen

2018-02-14

Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy to combat seasonal influenza infecti..

University of Melbourne Researchers