New Camkii Therapeutic Targets In Heart Failure With Preserved Ejection Fraction

Grant number: 1125453 | Funding period: 2017 - 2020

Active

Abstract

Deaths associated with impaired heart muscle relaxation and unstable cardiac cycle rhythm are increasing. The mechanisms by which these pathologies occur are not understood and clinical therapies are lacking. We have novel evidence to suggest that a key signalling protein, CaMKII, is critically involved in the development of these forms of heart pathology. This goal of this project is to identify how CaMKII is implicated in heart failure and dysrhythmia as a basis for designing new therapies.