MECHANISMS OF REGULATING GENE EXPRESSION VIA SELECTIVE MRNA TRANSPORT

Grant number: 1127745 | Funding period: 2017 - 2019

Completed

Abstract

A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms. This project aims to dissect the molecular mechanisms of regulating gene expression via selective mRNA transport. This will establish selective mRNA export as a novel area of research in cancer biology.

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Gregory J Goodall, Vihandha O Wickramasinghe

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While the processing of mRNA is essential for gene expression, recent findings have highlighted that RNA processing is systematica..

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Splicing and nuclear export of mRNA are critical steps in the gene expression pathway. While RNA processing factors can perform ge..

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Export of protein-coding and non-coding RNA molecules from the nucleus to the cytoplasm is critical for gene expression. This nece..

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Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversit..