MECHANISMS OF REGULATING GENE EXPRESSION VIA SELECTIVE MRNA TRANSPORT
Grant number: 1127745 | Funding period: 2017 - 2019
A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms. This project aims to dissect the molecular mechanisms of regulating gene expression via selective mRNA transport. This will establish selective mRNA export as a novel area of research in cancer biology.
Related publications (4)
Impact of Alternative Splicing on the Human Proteome
Yansheng Liu, Mar Gonzalez-Porta, Sergio Santos, Alvis Brazma, John C Marioni, Ruedi Aebersold, Ashok R Venkitaraman, Vihandha O Wickramasinghe
Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversit..