A RANDOMISED CONTROLLED TRIAL TO PREVENT ECZEMA, FOOD ALLERGY AND SENSITISATION USING A SKIN BARRIER IMPROVEMENT STRATEGY

Grant number: 1130010 | Funding period: 2017 - 2022

Completed

Abstract

In this world first study, we will test if building the infant skin barrier by using daily regular skin care treatment can reduce the incidence of eczema. If successful, this trial will alter infant skin care practices and reduce the burden of allergic diseases in our community. Furthermore, as infants with eczema having a poor skin barrier, which possibly increases their risk of developing sensitisation, we will test if this intervention reduces the risk of food allergy.

Related publications (1)

PEBBLES study protocol: a randomised controlled trial to prevent atopic dermatitis, food allergy and sensitisation in infants with a family history of allergic disease using a skin barrier improvement strategy

Adrian Lowe, John Su, Mimi Tang, Caroline J Lodge, Melanie Matheson, Katrina J Allen, George Varigos, Arun Sasi, Noel Cranswick, Simone Hamilton, Colin F Robertson, Jennie Hui, Michael Abramson, Shaie O'Brien, Shyamali Dharmage

2019-06-01

INTRODUCTION: The skin is an important barrier against environmental allergens, but infants have relatively impaired skin barrier ..

University of Melbourne Researchers

Adrian Lowe Melbourne School of Population and Global Health

Mimi Tang Paediatrics Royal Children's Hospital

Shyamali Dharmage Melbourne School of Population and Global Health