THE BIOGENESIS OF CYTOTOXIC GRANULES
Grant number: 1128587 | Funding period: 2017 - 2020
Cytotoxic lymphocytes are immune cells responsible for the killing infected or cancerous cells. How cytotoxic lymphocytes mature from a naive inactive to a fully activated state as they encounter infected or malignant cells is poorly understood, and will be investigated in the current proposal. Our results will aid in the development of novel therapies for cancer and other immunological diseases.
Related publications (4)
Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis
Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik
Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry
Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E Schadt, John J McNeil, Joseph A Trapani
<jats:p>In a population-based analysis including a large database restricted to patients over age 70, the authors demonstrate that..
Lipid order and charge protect killer T cells from accidental death
Jesse A Rudd-Schmidt, Adrian W Hodel, Tahereh Noori, Jamie A Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Bart W Hoogenboom, Ilia Voskoboinik
Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTL..