GENERATION OF PROTECTIVE IMMUNITY AGAINST SEVERE INFLUENZA DISEASE IN INDIGENOUS AUSTRALIANS

Grant number: 1122524 | Funding period: 2017 - 2020

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Abstract

Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.