LODGING RESIDENT MEMORY T CELLS IN THE RESPIRATORY TRACT AS AN APPROACH TO PROTECT AGAINST INFLUENZA VIRUS INFECTION

Grant number: 1120270 | Funding period: 2017 - 2019

Completed

Abstract

We have developed methods to deposit highly protective influenza fighting cells along the respiratory tract and we will apply these principles to develop better influenza virus vaccines

Related publications (5)

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Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

Angela Pizzolla, Thi HO Nguyen, Sneha Sant, Jade Jaffar, Tom Loudovaris, Stuart I Mannering, Paul G Thomas, Glen P Westall, Katherine Kedzierska, Linda M Wakim

2018-02-01

The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate ..

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Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells

Angela Pizzolla, Zhongfang Wang, Joanna R Groom, Katherine Kedzierska, Andrew G Brooks, Patrick C Reading, Linda M Wakim

2017-05-16

The lymphoid tissue that drains the upper respiratory tract represents an important induction site for cytotoxic T lymphocyte (CTL..

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Respiratory DC Use IFITM3 to Avoid Direct Viral Infection and Safeguard Virus-Specific CD8( ) T Cell Priming

Giuseppe Infusini, Jeffrey M Smith, He Yuan, Angela Pizzolla, Wy Ching Ng, Sarah L Londrigan, Ashraful Haque, Patrick C Reading, Jose A Villadangos, Linda M Wakim

2015-11-23

Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune responses to influenza virus. To do this..

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Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection

Sarah L Londrigan, Michelle D Tate, Emma R Job, Jessica M Moffat, Linda M Wakim, Christopher A Gonelli, Damien FJ Purcell, Andrew G Brooks, Jose A Villadangos, Patrick C Reading, Justine D Mintern

2015-11-13

BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 durin..

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Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 Tcells that are highly protective against influenza virus infection

LM Wakim, J Smith, I Caminschi, MH Lahoud, JA Villadangos

2015-09-01

Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of in..

University of Melbourne Researchers