LODGING RESIDENT MEMORY T CELLS IN THE RESPIRATORY TRACT AS AN APPROACH TO PROTECT AGAINST INFLUENZA VIRUS INFECTION
Grant number: 1120270 | Funding period: 2017 - 2019
We have developed methods to deposit highly protective influenza fighting cells along the respiratory tract and we will apply these principles to develop better influenza virus vaccines
Related publications (5)
Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles
Angela Pizzolla, Thi HO Nguyen, Sneha Sant, Jade Jaffar, Tom Loudovaris, Stuart I Mannering, Paul G Thomas, Glen P Westall, Katherine Kedzierska, Linda M Wakim
The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate ..
Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells
Angela Pizzolla, Zhongfang Wang, Joanna R Groom, Katherine Kedzierska, Andrew G Brooks, Patrick C Reading, Linda M Wakim
The lymphoid tissue that drains the upper respiratory tract represents an important induction site for cytotoxic T lymphocyte (CTL..
Respiratory DC Use IFITM3 to Avoid Direct Viral Infection and Safeguard Virus-Specific CD8( ) T Cell Priming
Giuseppe Infusini, Jeffrey M Smith, He Yuan, Angela Pizzolla, Wy Ching Ng, Sarah L Londrigan, Ashraful Haque, Patrick C Reading, Jose A Villadangos, Linda M Wakim
Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune responses to influenza virus. To do this..
Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection
Sarah L Londrigan, Michelle D Tate, Emma R Job, Jessica M Moffat, Linda M Wakim, Christopher A Gonelli, Damien FJ Purcell, Andrew G Brooks, Jose A Villadangos, Patrick C Reading, Justine D Mintern
BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 durin..
Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 Tcells that are highly protective against influenza virus infection
LM Wakim, J Smith, I Caminschi, MH Lahoud, JA Villadangos
Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of in..