A Randomised Controlled Trial (Rct) of Azithromycin Versus Doxycycline for the Treatment of Rectal Chlamydia Infection in Men.

Grant number: 1124172 | Funding period: 2017 - 2019

Completed

Abstract

Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.

Related publications (3)

Azithromycin or doxycycline for asymptomatic rectal chlamydia trachomatis

A Lau, FYS Kong, CK Fairley, DJ Templeton, J Amin, S Phillips, M Law, MY Chen, CS Bradshaw, B Donovan, A McNulty, MA Boyd, P Timms, EPF Chow, DG Regan, C Khaw, DA Lewis, J Kaldor, M Ratnayake, N Carvalho

2021-06-24

Background: Rectal chlamydia is a common bacterial sexually transmissible infection among men who have sex with men. Data from ran..

TREATMENT EFFICACY OF 1G AZITHROMYCIN VERSUS 100MG DOXYCYCLINE BI-DAILY FOR SEVEN DAYS FOR ASYMPTOMATIC RECTAL CHLAMYDIA TRACHOMATIS

2021-01-01

Treatment efficacy of azithromycin 1 g single dose versus doxycycline 100 mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol

A Lau, F Kong, CK Fairley, B Donovan, M Chen, C Bradshaw, M Boyd, J Amin, P Timms, S Tabrizi, DG Regan, DA Lewis, A McNulty, JS Hocking

2017-01-06

Background: Rectal infection with Chlamydia trachomatis is one of the most common bacterial sexually transmissible infections amon..

University of Melbourne Researchers

Jane Hocking

Catriona Bradshaw

Natalie Carvalho