A RANDOMISED CONTROLLED TRIAL (RCT) OF AZITHROMYCIN VERSUS DOXYCYCLINE FOR THE TREATMENT OF RECTAL CHLAMYDIA INFECTION IN MEN.
Grant number: 1124172 | Funding period: 2017 - 2019
Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.
Related publications (2)
Azithromycin or Doxycycline for Asymptomatic Rectal Chlamydia trachomatis
Andrew Lau, Fabian YS Kong, Christopher K Fairley, David J Templeton, Janaki Amin, Samuel Phillips, Matthew Law, Marcus Y Chen, Catriona S Bradshaw, Basil Donovan, Anna McNulty, Mark A Boyd, Peter Timms, Eric PF Chow, David G Regan, Carole Khaw, David A Lewis, John Kaldor, Mahesh Ratnayake, Natalie Carvalho
BACKGROUND: Rectal chlamydia is a common bacterial sexually transmissible infection among men who have sex with men. Data from ran..
Treatment efficacy of azithromycin 1 g single dose versus doxycycline 100 mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol
Andrew Lau, Fabian Kong, Christopher K Fairley, Basil Donovan, Marcus Chen, Catriona Bradshaw, Mark Boyd, Janaki Amin, Peter Timms, Sepehr Tabrizi, David G Regan, David A Lewis, Anna McNulty, Jane S Hocking
BACKGROUND: Rectal infection with Chlamydia trachomatis is one of the most common bacterial sexually transmissible infections amon..