IMMUNE SURVEILLANCE OF THE CNS DURING MALARIA INFECTION

Abstract

Infections in the central nervous system (CNS) can have profound neurological complications. Neurological disease caused by cerebral malaria (CM) is a lethal complication in humans. We have established a new model of longitudinal imaging of T cell responses in the brain during experimental CM in mice infected with Plasmodium berghei ANKA. This project will investigate the mechanisms of CNS injury and provide fundamental information about T cell responses in the CNS during infection.

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2021-09-15

In the Plasmodium berghei ANKA mouse model of malaria, accumulation of CD8+ T cells and infected RBCs in the brain promotes the de..