IMMUNE SURVEILLANCE OF THE CNS DURING MALARIA INFECTION
Grant number: 1124830 | Funding period: 2017 - 2019
Infections in the central nervous system (CNS) can have profound neurological complications. Neurological disease caused by cerebral malaria (CM) is a lethal complication in humans. We have established a new model of longitudinal imaging of T cell responses in the brain during experimental CM in mice infected with Plasmodium berghei ANKA. This project will investigate the mechanisms of CNS injury and provide fundamental information about T cell responses in the CNS during infection.
Related publications (1)
CD8( ) and CD4( ) T Cells Infiltrate into the Brain during Plasmodium berghei ANKA Infection and Form Long-Term Resident Memory
Nazanin Ghazanfari, Julia L Gregory, Sapna Devi, Daniel Fernandez-Ruiz, Lynette Beattie, Scott N Mueller, William R Heath
In the Plasmodium berghei ANKA mouse model of malaria, accumulation of CD8+ T cells and infected RBCs in the brain promotes the de..