A Simple Method to Improve Stem Cell Transplant Therapy

Grant number: 1120714 | Funding period: 2017 - 2020

Completed

Abstract

Despite the success of hematopoietic stem cell transplantation and years of promise, almost all other stem cell therapies are considered experimental and remain in preclinical or early-phase clinical testing. This study aims to improve the efficiency of stem cell transplantation by manipulating cellular metabolism prior to transplantation, if effective these results may offer hope to patients suffering from a broad range of disorders.

Related publications (7)

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A Metabolic Roadmap for Somatic Stem Cell Fate

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While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bioenergetic demands, rece..

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Aging and Skeletal Muscle

Gordon S Lynch

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Some of the most serious consequences of aging are its effects on skeletal muscle particularly the progressive loss of mass and fu..

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The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

JH Nguyen, JD Chung, GS Lynch, JG Ryall

2019-10-29

Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle ..

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GS Lynch, R Koopman

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Nature's paradox in skeletal muscle describes the seemingly mutually exclusive relationship between muscle fibre size and oxidativ..

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Dietary meat and protection against sarcopenia

GS Lynch, R Koopman

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Sarcopenia describes the age-related loss of skeletal muscle mass and associated muscle weakness. Sarcopenia is a major global hea..

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The molecular signature of muscle stem cells is driven by nutrient availability and innate cell metabolism

JG Ryall, GS Lynch

2018-07-01

Purpose of review To discuss how innate muscle stem-cell metabolism and nutrient availability can provide temporal regulation of c..

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Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

RJ Mills, DM Titmarsh, X Koenig, BL Parker, JG Ryall, GA Quaife-Ryan, HK Voges, MP Hodson, C Ferguson, L Drowley, AT Plowright, EJ Needham, QD Wang, P Gregorevic, M Xin, WG Thomas, RG Parton, LK Nielsen, BS Launikonis, DE James

2017-10-03

The mammalian heart undergoes maturation during postnatal life to meet the increased functional requirements of an adult. However,..

University of Melbourne Researchers