THE ROLE OF NOVEL AND ESSENTIAL BROMODOMAIN PROTEINS IN COORDINATING MALARIA PARASITE GENE REGULATION AND THEIR POTENTIAL AS ANTI-MALARIAL TARGETS
Grant number: 1128975 | Funding period: 2017 - 2020
Malaria kills over 400,000 people a year and new therapies are needed. Malaria parasites activate groups of genes by novel mechanisms that could be targeted by drugs. We will characterise a novel group of proteins to identify those that activate genes essential for parasite survival. We will also search for molecules that inhibit the proteins and kill malaria parasites. Thus we will discover how parasites control their genes and identify drug targets and inhibitors for drug development.
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Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences
Jingyi Tang, Scott A Chisholm, Lee M Yeoh, Paul R Gilson, Anthony T Papenfuss, Karen P Day, Michaela Petter, Michael F Duffy
BACKGROUND: The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nu..