CHARACTERISATION OF ANTI-HBS RESPONSES IN PATIENTS UNDERGOING FUNCTIONAL HEPATITIS B CURE: IMPLICATION FOR FUTURE THERAPIES
Grant number: 1127538 | Funding period: 2017 - 2020
The hepatitis B virus causes liver cirrhosis and liver cancer. There is no cure for hepatitis B. However, a small number of patients can naturally rid themselves of the virus. We have identified 14 of these individuals and discovered that they have a unique immune response that is responsible for these “natural” cures. We plan to characterise this immune response and turn it into a therapeutic vaccine which can be used to cure patients who are still chronically infected.
Related publications (4)
Glycoengineered hepatitis B virus-like particles with enhanced immunogenicity
Carina CD Joe, Sayantani Chatterjee, George Lovrecz, Timothy E Adams, Morten Thaysen-Andersen, Renae Walsh, Stephen A Locarnini, Peter Smooker, Hans J Netter
Virus-like particles (VLP) represent biological platforms for the development of novel products such as vaccines and delivery plat..
Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes
Lilly KW Yuen, Margaret Littlejohn, Sebastian Duchene, Rosalind Edwards, Sarah Bukulatjpi, Paula Binks, Kathy Jackson, Jane Davies, Joshua S Davis, Steven YC Tong, Stephen Locarnini
The entry point and timing of ancient human migration into continental Sahul (the combined landmass of Australia, New Guinea, and ..
Hepatitis B virus-like particles expressing Plasmodium falciparum epitopes induce complement-fixing antibodies against the circumsporozoite protein
Natalie J Kingston, Liriye Kurtovic, Renae Walsh, Carina Joe, George Lovrecz, Stephen Locarnini, James G Beeson, Hans J Netter
The repetitive structure of compact virus-like particles (VLPs) provides high density displays of antigenic sequences, which trigg..