DEVELOPMENT OF A HIGH ACUITY, DIAMOND RETINAL PROSTHESIS

Improved wetting of gold active braze alloy on diamond for use in medical implants

K Edalati, M Stamp, K Ganesan, A Stacey, G Martin-Hardy, R Fontaine, S Prawer, DJ Garrett

2020-11-01

Medical implants containing active electronics must have a leak-proof encapsulation to be certified as safe for human use. Implant..

Hermetic fusion of diamond micro-components with silicon

Melanie EM Stamp, Alastair Stacey, Kate Fox, Steven Prawer, David J Garrett

2020-10-01

Implantable devices which interact with neuronal systems and last for the lifetime of the recipient are an emerging field in medic..

Minimizing axon bundle activation of retinal ganglion cells with oriented rectangular electrodes.

Wei Tong, Maryam Hejazi, David J Garrett, Timothy Esler, Steven Prawer, Hamish Meffin, Michael Ibbotson

2020-06-17

OBJECTIVE: Retinal prostheses aim to restore vision in patients with retinal degenerative diseases, such as age-related macular de..

Stimulation Strategies for Improving the Resolution of Retinal Prostheses.

Wei Tong, Hamish Meffin, David J Garrett, Michael R Ibbotson

2020-03-26

Electrical stimulation using implantable devices with arrays of stimulating electrodes is an emerging therapy for neurological dis..

3D Diamond Electrode Array for High-Acuity Stimulation in Neural Tissue

MEM Stamp, W Tong, K Ganesan, S Prawer, MR Ibbotson, DJ Garrett

2020-03-16

Innovations in micro-and nanofabrication technologies enable the manufacture of multielectrode arrays for use in neuromodulation a..

Improved visual acuity using a retinal implant and an optimized stimulation strategy

Wei Tong, Melanie Stamp, Nicholas Apollo, Kumaravelu Ganesan, Hamish Meffin, Steven Prawer, David J Garrett, Michael R Ibbotson

2020-02-01

Objective. Retinal prosthetic devices hold great promise for the treatment of retinal degenerative diseases such as retinitis pigm..

Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina

Kerry J Halupka, Carla J Abbott, Yan T Wong, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Evgeni N Sergeev, Chi D Luu, Alice Brandli, Penelope J Allen, Hamish Meffin, Mohit N Shivdasani

2017-07-01

Purpose: Simultaneous stimulation of multiple retinal electrodes in normally sighted animals shows promise in improving the resolu..

Diamond Devices for High Acuity Prosthetic Vision

Arman Ahnood, Hamish Meffin, David J Garrett, Kate Fox, Kumaravelu Ganesan, Alastair Stacey, Nicholas V Apollo, Yan T Wong, Samantha G Lichter, William Kentler, Omid Kavehei, Ursula Greferath, Kirstan A Vessey, Michael R Ibbotson, Erica L Fletcher, Anthony N Burkitt, Steven Prawer

2017-02-01

Retinal implants restore a sense of vision, for a growing number of users worldwide. Nevertheless, visual acuities provided by the..

Prediction of cortical responses to simultaneous electrical stimulation of the retina

Kerry J Halupka, Mohit N Shivdasani, Shaun L Cloherty, David B Grayden, Yan T Wong, Anthony N Burkitt, Hamish Meffin

2017-02-01

OBJECTIVE: Simultaneous electrical stimulation of multiple electrodes has shown promise in diversifying the responses that can be ..

Brazing techniques for the fabrication of biocompatible carbon-based electronic devices

Nicholas V Apollo, Desmond Lau, Arman Ahnood, Alastair Stacey, Kumaravelu Ganesan, Samantha G Lichter, Kate Fox, Javad Foroughi, Hamish Meffin, Gordon G Wallace, Ray Baughman, Steven Prawer, David J Garrett

2016-10-01

Prototype electronic devices have been critical to the discovery and demonstration of the unique properties of new materials, incl..

Optimizing growth and post treatment of diamond for high capacitance neural interfaces

Wei Tong, Kate Fox, Akram Zamani, Ann M Turnley, Kumaravelu Ganesan, Arman Ahnood, Rosemary Cicione, Hamish Meffin, Steven Prawer, Alastair Stacey, David J Garrett

2016-10-01

Electrochemical and biological properties are two crucial criteria in the selection of the materials to be used as electrodes for ..

Diamond for neural interfacing: A review

David J Garrett, Wei Tong, David A Simpson, Hamish Meffin

2016-06-01

The variety of materials that fall in the diamond category is vast and increasing. From single, to micro to nano-crystalline, diam..

Spectral distribution of local field potential responses to electrical stimulation of the retina

Yan T Wong, Kerry Halupka, Tatiana Kameneva, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Hamish Meffin, Mohit N Shivdasani

2016-06-01

OBJECTIVE: Different frequency bands of the local field potential (LFP) have been shown to reflect neuronal activity occurring at ..

A Simple and Accurate Model to Predict Responses to Multi-electrode Stimulation in the Retina

Matias I Maturana, Nicholas V Apollo, Alex E Hadjinicolaou, David J Garrett, Shaun L Cloherty, Tatiana Kameneva, David B Grayden, Michael R Ibbotson, Hamish Meffin

2016-04-01

Implantable electrode arrays are widely used in therapeutic stimulation of the nervous system (e.g. cochlear, retinal, and cortica..

Development of a Magnetic Attachment Method for Bionic Eye Applications

Kate Fox, Hamish Meffin, Owen Burns, Carla J Abbott, Penelope J Allen, Nicholas L Opie, Ceara McGowan, Jonathan Yeoh, Arman Ahnood, Chi D Luu, Rosemary Cicione, Alexia L Saunders, Michelle McPhedran, Lisa Cardamone, Joel Villalobos, David J Garrett, David AX Nayagam, Nicholas V Apollo, Kumaravelu Ganesan, Mohit N Shivdasani

2016-03-01

Successful visual prostheses require stable, long-term attachment. Epiretinal prostheses, in particular, require attachment method..

Retinal ganglion cells: mechanisms underlying depolarization block and differential responses to high frequency electrical stimulation of ON and OFF cells

T Kameneva, MI Maturana, AE Hadjinicolaou, SL Cloherty, MR Ibbotson, DB Grayden, AN Burkitt, H Meffin

2016-02-01

OBJECTIVE: ON and OFF retinal ganglion cells (RGCs) are known to have non-monotonic responses to increasing amplitudes of high fre..

A computational model of orientation-dependent activation of retinal ganglion cells

Timothy Esler, Anthony N Burkitt, David B Grayden, Robert R Kerr, Bahman Tahayori, Hamish Meffin

2016-01-01

Currently, a challenge in electrical stimulation for epiretinal prostheses is the avoidance of stimulation of axons of passage in ..

In vivo biocompatibility of boron doped and nitrogen included conductive-diamond for use in medical implants

David J Garrett, Alexia L Saunders, Ceara McGowan, Joscha Specks, Kumaravelu Ganesan, Hamish Meffin, Richard A Williams, David AX Nayagam

2016-01-01

Recently, there has been interest in investigating diamond as a material for use in biomedical implants. Diamond can be rendered e..

Spatial phase sensitivity of complex cells in primary visual cortex depends on stimulus contrast

H Meffin, MA Hietanen, SL Cloherty, MR Ibbotson

2015-12-01

Neurons in primary visual cortex are classified as simple, which are phase sensitive, or complex, which are significantly less pha..

Prosthetic vision: devices, patient outcomes and retinal research

Alex E Hadjinicolaou, Hamish Meffin, Matias I Maturana, Shaun L Cloherty, Michael R Ibbotson

2015-09-01

Retinal disease and its associated retinal degeneration can lead to the loss of photoreceptors and therefore, profound blindness. ..

Hermetic diamond capsules for biomedical implants enabled by gold active braze alloys

Samantha G Lichter, Mathilde C Escudie, Alastair D Stacey, Kumaravelu Ganesan, Kate Fox, Arman Ahnood, Nicholas V Apollo, Dunstan C Kua, Aaron Z Lee, Ceara McGowan, Alexia L Saunders, Owen Burns, David AX Nayagam, Richard A Williams, David J Garrett, Hamish Meffin, Steven Prawer

2015-06-01

As the field of biomedical implants matures the functionality of implants is rapidly increasing. In the field of neural prostheses..

Spike history neural response model

Tatiana Kameneva, Miganoosh Abramian, Daniele Zarelli, Dragan Nesic, Anthony N Burkitt, Hamish Meffin, David B Grayden

2015-06-01

There is a potential for improved efficacy of neural stimulation if stimulation levels can be modified dynamically based on the re..

Ultrananocrystalline diamond-CMOS device integration route for high acuity retinal prostheses

A Ahnood, MC Escudie, R Cicione, CD Abeyrathne, K Ganesan, KE Fox, DJ Garrett, A Stacey, NV Apollo, SG Lichter, CDL Thomas, N Tran, H Meffin, S Prawer

2015-06-01

High density electrodes are a new frontier for biomedical implants. Increasing the density and the number of electrodes used for t..

Broadband Onset Inhibition Can Suppress Spectral Splatter in the Auditory Brainstem

Martin J Spencer, David AX Nayagam, Janine C Clarey, Antonio G Paolini, Hamish Meffin, Anthony N Burkitt, David B Grayden

2015-05-15

In vivo intracellular responses to auditory stimuli revealed that, in a particular population of cells of the ventral nucleus of t..

The bionic eye: A review of multielectrode arrays

K Fox, O Burns, DJ Garrett, MN Shivdasani, H Meffin

2015-01-01

The notion of creating artificial vision using visual prostheses has been well represented though science fiction literature and f..

The effects of temperature changes on retinal ganglion cell responses to electrical stimulation

MI Maturana, NV Apollo, DJ Garrett, T Kameneva, H Meffin, MR Ibbotson, SL Cloherty, D GRAYDEN

2015-01-01

Little is known about how the retina's response to electrical stimulation is modified by temperatures. In vitro experiments are of..

Fabrication of planarised conductively patterned diamond for bio-applications

Wei Tong, Kate Fox, Kumaravelu Ganesan, Ann M Turnley, Olga Shimoni, Phong A Tran, Alexander Lohrmann, Thomas McFarlane, Arman Ahnood, David J Garrett, Hamish Meffin, Neil M O'Brien-Simpson, Eric C Reynolds, Steven Prawer

2014-10-01

The development of smooth, featureless surfaces for biomedical microelectronics is a challenging feat. Other than the traditional ..