Defining a novel mechanism of pathogen detection conserved in mammals

Differential antigen requirements by diverse MR1-restricted T cells (vol 100, pg 112, 2022)

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

2022-02-15

Correction to: Immunol Cell Biol 2022; 100: 112–126; https://doi.org/10.1111/imcb.12519 The authors omitted a grant from the Natio..

Differential antigenic requirements by diverse MR1-restricted T cells

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

2022-01-13

MHC-related protein 1 (MR1) presents microbial riboflavin metabolites to mucosal-associated invariant T (MAIT) cells for surveilla..

MAIT cells accumulate in ovarian cancer-elicited ascites where they retain their capacity to respond to MR1 ligands and cytokine cues

Tony Yao, Patrick T Rudak, Celine M Laumont, Alex R Michaud, Rasheduzzaman Rashu, Natasha N Knier, Paula J Foster, Hamish EG McWilliam, Jose A Villadangos, Brad H Nelson, Gabriel E DiMattia, Trevor G Shepherd, SM Mansour Haeryfar

2021-12-02

The low mutational burden of epithelial ovarian cancer (EOC) is an impediment to immunotherapies that rely on conventional MHC-res..

CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.

Nicholas A Gherardin, Samuel J Redmond, Hamish EG McWilliam, Catarina F Almeida, Katherine HA Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J Ross, Catriona V Nguyen-Robertson, Shian Su, Matthew E Ritchie, Jose A Villadangos, D Branch Moody, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

2021-06-25

CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool...

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos

2020-10-06

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey

2020-07-10

The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..

MR1: a multi-faceted metabolite sensor for T cell activation

Hamish EG McWilliam, Jose A Villadangos

2020-06-01

The major histocompatibility complex class I-related molecule MR1 captures and presents small metabolites to MR1- restricted T cel..

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

Antoine Roquilly, Cedric Jacqueline, Marion Davieau, Alice Molle, Abderrahmane Sadek, Cynthia Fourgeux, Paul Rooze, Alexis Broquet, Barbara Misme-Aucouturier, Tanguy Chaumette, Mickael Vourc'h, Raphael Cinotti, Nadege Marec, Vanessa Gauttier, Hamish EG McWilliam, Frederic Altare, Jeremie Poschmann, Jose A Villadangos, Karim Asehnoune

2020-05-18

Sepsis and trauma cause inflammation and elevated susceptibility to hospital-acquired pneumonia. As phagocytosis by macrophages pl..

Characterisation of serum IgG(T) responses to potential diagnostic antigens for equine cyathostominosis

Thomas Tzelos, Kathrin K Geyer, Mairi C Mitchell, Hamish EG McWilliam, Vitaliy O Kharchenko, Stewart TG Burgess, Jacqueline B Matthews

2020-04-01

Cyathostomins are ubiquitous parasitic nematodes of horses. These worms spend substantial periods as intestinal wall stage encyste..

Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

2020-04-01

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..

Virus-Mediated Suppression of the Antigen Presentation Molecule MR1

Brian P McSharry, Carolyn Samer, Hamish EG McWilliam, Caroline L Ashley, Michael B Yee, Megan Steain, Ligong Liu, David P Fairlie, Paul R Kinchington, James McCluskey, Allison Abendroth, Jose A Villadangos, Jamie Rossjohn, Barry Slobedman

2020-03-03

The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invari..

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

2019-05-29

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade ..

MR1 antigen presentation to MAIT cells: new ligands, diverse pathways?

Hamish EG McWilliam, Jose A Villadangos

2018-06-01

The major histocompatibility complex class I-related molecule MR1 is the only antigen (Ag) presenting molecule that captures and d..