Mathematical and statistical modelling of antimalarial drug action
Grant number: DE170100785 | Funding period: 2017 - 2020
This project aims to develop a mathematical model to optimise global antimalarial treatment policy. Malaria-causing parasites are resistant to the most potent antimalarial drug available. If left unaddressed, a catastrophic rise in global malaria incidence and mortality could occur. Changes to global antimalarial treatment policy increasingly rely on mathematical models, but they do not encompass recent breakthroughs in antimalarial drug action and the immune response. This project’s model is expected to improve antimalarial drug dosing regimens and control the spread of antimalarial drug resistance.
Related publications (3)
In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance
Sophie G Zaloumis, Pengxing Cao, Saber Dini, Miles P Davenport, Deborah Cromer, David S Khoury, Freya JI Fowkes, James M McCaw, Julie A Simpson
Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug. With the emergence of resis..