Learning to breathe: emerging inhibition of sensory relay mechanisms.
Grant number: DP170104861 | Funding period: 2017 - 2019
This project aims to investigate the maturation of the respiratory network from a functional to synaptic level. The brain generates motor commands for every single breath. After birth, the respiratory network matures to adapt breathing to emotional and behavioural demands. The mature respiratory network actively inhibits sensory feedback to express learned breathing patterns associated with motor behaviour such as speech. This project expects to provide the foundation for understanding the hierarchical organisation and plasticity of motor circuits in the brain as it acquires learned motor patterns.
Related publications (12)
The pontine Kolliker-Fuse nucleus gates facial, hypoglossal, and vagal upper airway related motor activity
M Dutschmann, TG Bautista, P Trevizan-Bau, RR Dhingra, W Furuya
The pontine Kölliker-Fuse nucleus (KFn) is a core nucleus of respiratory network that mediates the inspiratory-expiratory phase tr..
Forebrain projection neurons target functionally diverse respiratory control areas in the midbrain, pons, and medulla oblongata
Pedro Trevizan-Bau, Rishi R Dhingra, Werner I Furuya, Davor Stanic, Stuart B Mazzone, Mathias Dutschmann
Eupnea is generated by neural circuits located in the ponto-medullary brainstem, but can be modulated by higher brain inputs which..
The role of glycinergic inhibition in respiratory pattern formation and cardio-respiratory coupling in rats.
Werner Issao Furuya, Rishi R Dhingra, Pedro Trevizan-Baú, Robin M McAllen, Mathias Dutschmann
Cardio-respiratory coupling is reflected as respiratory sinus arrhythmia (RSA) and inspiratory-related bursting of sympathetic ner..
Influences of GABAergic Inhibition in the Dorsal Medulla on Contralateral Swallowing Neurons in Rats
Shota Kinoshita, Yoichiro Sugiyama, Keiko Hashimoto, Shinya Fuse, Shigeyuki Mukudai, Toshiro Umezaki, Mathias Dutschmann, Shigeru Hirano
OBJECTIVES: We aimed to examine the effect of unilateral inhibition of the medullary dorsal swallowing networks on the activities ..
Volumetric mapping of the functional neuroanatomy of the respiratory network in the perfused brainstem preparation of rats
Rishi R Dhingra, Thomas E Dick, Werner I Furuya, Roberto F Galan, Mathias Dutschmann
KEY POINTS: The functional neuroanatomy of the mammalian respiratory network is far from being understood since experimental tools..
Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat
Werner I Furuya, Rishi R Dhingra, Andrew L Gundlach, Mohammad Akhter Hossain, Mathias Dutschmann
The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal..
Excitation-inhibition balance regulates the patterning of spinal and cranial inspiratory motor outputs in rats in situ
Rishi R Dhingra, Werner I Furuya, Roberto F Galan, Mathias Dutschmann
Spinal phrenic nerve activity (PNA) drives the diaphragm but cranial hypoglossal nerve activity (HNA) also expresses synchronous a..
Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation
Rishi R Dhingra, Werner Furuya, Tara G Bautista, Thomas E Dick, Roberto F Galan, Mathias Dutschmann
The core circuit of the respiratory central pattern generator (rCPG) is located in the ventrolateral medulla, especially in the pr..
Expression of the transcription factor FOXP2 in brainstem respiratory circuits of adult rat is restricted to upper-airway pre-motor areas
Davor Stanic, Rishi R Dhingra, Mathias Dutschmann
Expression of the transcription factor FOXP2 is linked to brain circuits that control motor function and speech. Investigation of ..