Learning to breathe: emerging inhibition of sensory relay mechanisms.

Grant number: DP170104861 | Funding period: 2017 - 2019

Completed

Abstract

This project aims to investigate the maturation of the respiratory network from a functional to synaptic level. The brain generates motor commands for every single breath. After birth, the respiratory network matures to adapt breathing to emotional and behavioural demands. The mature respiratory network actively inhibits sensory feedback to express learned breathing patterns associated with motor behaviour such as speech. This project expects to provide the foundation for understanding the hierarchical organisation and plasticity of motor circuits in the brain as it acquires learned motor patterns.

Related publications (15)

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The rostral brainstem's pivotal role in swallow-breathing coordination

M Dutschmann

2022-05-01

Respiration and swallowing are motor behaviours that require the interaction of two brainstem central pattern generators (r-CPG, s..

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Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat

Pedro Trevizan-Bau, Werner Furuya, Stuart B Mazzone, Davor Stanic, Rishi R Dhingra, Mathias Dutschmann

2021-02-18

Synaptic activities of the periaqueductal gray (PAG) can modulate or appropriate the respiratory motor activities in the context o..

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The pontine Kolliker-Fuse nucleus gates facial, hypoglossal, and vagal upper airway related motor activity

M Dutschmann, TG Bautista, P Trevizan-Bau, RR Dhingra, W Furuya

2021-02-01

The pontine Kölliker-Fuse nucleus (KFn) is a core nucleus of respiratory network that mediates the inspiratory-expiratory phase tr..

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Forebrain projection neurons target functionally diverse respiratory control areas in the midbrain, pons, and medulla oblongata

Pedro Trevizan-Bau, Rishi R Dhingra, Werner I Furuya, Davor Stanic, Stuart B Mazzone, Mathias Dutschmann

2021-01-05

Eupnea is generated by neural circuits located in the ponto-medullary brainstem, but can be modulated by higher brain inputs which..

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The role of glycinergic inhibition in respiratory pattern formation and cardio-respiratory coupling in rats.

Werner Issao Furuya, Rishi R Dhingra, Pedro Trevizan-Baú, Robin M McAllen, Mathias Dutschmann

2021-01-01

Cardio-respiratory coupling is reflected as respiratory sinus arrhythmia (RSA) and inspiratory-related bursting of sympathetic ner..

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Response to: The post-inspiratory complex (PiCo), what is the evidence?

Rishi R Dhingra, Werner I Furuya, Thomas E Dick, Mathias Dutschmann

2020-12-01

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Influences of GABAergic Inhibition in the Dorsal Medulla on Contralateral Swallowing Neurons in Rats

Shota Kinoshita, Yoichiro Sugiyama, Keiko Hashimoto, Shinya Fuse, Shigeyuki Mukudai, Toshiro Umezaki, Mathias Dutschmann, Shigeru Hirano

2020-11-04

OBJECTIVES: We aimed to examine the effect of unilateral inhibition of the medullary dorsal swallowing networks on the activities ..

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Volumetric mapping of the functional neuroanatomy of the respiratory network in the perfused brainstem preparation of rats

Rishi R Dhingra, Thomas E Dick, Werner I Furuya, Roberto F Galan, Mathias Dutschmann

2020-04-16

KEY POINTS: The functional neuroanatomy of the mammalian respiratory network is far from being understood since experimental tools..

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Volumetric mapping of the functional neuroanatomy of the brainstem respiratory network in the perfused brainstem preparation of rats

Rishi Dhingra, Thomas Dick, Werner Furuya, Roberto Galan, Mathias Dutschmann

2020-04-01

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Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat

Werner I Furuya, Rishi R Dhingra, Andrew L Gundlach, Mohammad Akhter Hossain, Mathias Dutschmann

2020-01-01

The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal..

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Excitation-inhibition balance regulates the patterning of spinal and cranial inspiratory motor outputs in rats in situ

Rishi R Dhingra, Werner I Furuya, Roberto F Galan, Mathias Dutschmann

2019-08-01

Spinal phrenic nerve activity (PNA) drives the diaphragm but cranial hypoglossal nerve activity (HNA) also expresses synchronous a..

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Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation

Rishi R Dhingra, Werner Furuya, Tara G Bautista, Thomas E Dick, Roberto F Galan, Mathias Dutschmann

2019-07-23

The core circuit of the respiratory central pattern generator (rCPG) is located in the ventrolateral medulla, especially in the pr..

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Thoracic sympathetic chain stimulation modulates and entrains the respiratory pattern

RR Dhingra, G Kola, SJ Lewis, M Dutschmann

2019-05-01

Stimulation of thoracic sympathetic chain (TSC) afferents has been shown to slow the respiratory rhythm in dogs, monkeys and human..

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Expression of the transcription factor FOXP2 in brainstem respiratory circuits of adult rat is restricted to upper-airway pre-motor areas

Davor Stanic, Rishi R Dhingra, Mathias Dutschmann

2018-04-01

Expression of the transcription factor FOXP2 is linked to brain circuits that control motor function and speech. Investigation of ..

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Kolliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism

Rishi R Dhingra, Mathias Dutschmann, Roberto F Galan, Thomas E Dick

2017-02-01

Respiration varies from breath to breath. On the millisecond timescale of spiking, neuronal circuits exhibit variability due to th..