Defining The Early Structural Assembly Of High-Density Lipoproteins

Grant number: DP170104046 | Funding period: 2017 - 2020

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Abstract

This project aims to study the interaction between proteins and lipids, a fundamental aspect of cellular processes in all organisms. Lipid binding by apoA-I forms high-density lipoproteins (HDL) in the bloodstream, which removes cholesterol from the body. This project will define the types of lipids that bind first to the apolipoprotein (apo) A-I and the structural mechanisms of this process. The conformation of lipid binding proteins often changes during lipid binding. However, the structural mechanisms and conformational rearrangements are poorly understood. This project expects to understand the function of HDL and the structural mechanisms of lipid binding proteins in general. The result..

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