How does calcium make the heart grow?
Grant number: DP170101358 | Funding period: 2017 - 2020
This project aims to develop a mathematical model of calcium signalling in heart cells to understand how calcium makes the heart grow. Our hearts grow to adapt to long-term changes, such as during development and in pregnancy or heart disease. Biochemical reactions involving calcium control the growth of heart cells and heart cells also use calcium signalling to trigger contraction with each beat. How calcium controls the heartbeat and regulates cell growth is unknown. This project will develop a new mathematical model of calcium signalling in heart cells to understand important cellular adaption processes. This knowledge will lead to the ability to independently control cellular pathways me..View full description
Related publications (12)
Ca2 Release via IP3 Receptors Shapes the Cardiac Ca2 Transient for Hypertrophic Signaling.
Hilary Hunt, Agnė Tilūnaitė, Greg Bass, Christian Soeller, H Llewelyn Roderick, Vijay Rajagopal, Edmund J Crampin
Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocyte..
Ca2 release via IP3Rs increases RyR mediated Ca2 spark frequency in ventricular cardiomyocytes without altering spark amplitude and duration
Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Llewelyn Roderick, Edmund Crampin, Vijay Rajagopal
Abstract Calcium plays critical roles in cardiac cells, coupling electrical excitation to mechanical contraction with each heartbe..
Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release
David Ladd, Agne Tilunaite, H Llewelyn Roderick, Christian Soeller, Edmund J Crampin, Vijay Rajagopal
Calcium signaling plays a pivotal role in cardiomyocytes, coupling electrical excitation to mechanical contraction of the heart. D..
Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture
Shouryadipta Ghosh, Kenneth Tran, Lea Delbridge, Anthony Hickey, Eric Hanssen, Edmund Crampin, Vijay Rajagopal
Abstract Recent electron microscopy data have revealed that cardiac mitochondria are not arranged in crystalline columns, but are ..