Engineering Multifunctional Particles for Biological Applications
Grant number: DP170103331 | Funding period: 2017 - 2019
This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biological barriers. This project will develop a platform for the assemble of particles with tailored properties which are expected to provide insights on particle-biological interactions for particle-based therapeutic delivery.
Related publications (24)
Particle engineering enabled by polyphenol-mediated supramolecular networks.
Jiajing Zhou, Zhixing Lin, Matthew Penna, Shuaijun Pan, Yi Ju, Shiyao Li, Yiyuan Han, Jingqu Chen, Gan Lin, Joseph J Richardson, Irene Yarovsky, Frank Caruso
We report a facile strategy for engineering diverse particles based on the supramolecular assembly of natural polyphenols and a se..
Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition
Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso
Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. Th..
Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.
Wenjie Zhang, Quinn A Besford, Andrew J Christofferson, Patrick Charchar, Joseph J Richardson, Aaron Elbourne, Kristian Kempe, Christoph E Hagemeyer, Matthew R Field, Chris F McConville, Irene Yarovsky, Frank Caruso
The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key chall..
Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials
Yiyuan Han, Zhixing Lin, Jiajing Zhou, Gyeongwon Yun, Rui Guo, Joseph J Richardson, Frank Caruso
Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins..
Ordered Mesoporous Metal-Phenolic Network Particles.
Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso
Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..
Self-Assembly of a Metal-Phenolic Sorbent for Broad-Spectrum Metal Sequestration
Md Arifur Rahim, Gan Lin, Pietro Pacchin Tomanin, Yi Ju, Anders Barlow, Mattias Bjornmalm, Frank Caruso
Metal contamination of water bodies from industrial effluents presents a global threat to the aquatic ecosystem. To address this c..
The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints
G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso
The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent stud..
Modular Assembly of Host-Guest Metal-Phenolic Networks Using Macrocyclic Building Blocks
Shuaijun Pan, Rui Guo, Nadja Bertleff-Zieschang, Shanshan Li, Quinn A Besford, Qi-Zhi Zhong, Gyeongwon Yun, Yunti Zhang, Francesca Cavalieri, Yi Ju, Eirini Goudeli, Joseph J Richardson, Frank Caruso
The manipulation of interfacial properties has broad implications for the development of high‐performance coatings. Metal–phenolic..
Expanding the Toolbox of Metal-Phenolic Networks via Enzyme-Mediated Assembly
Qi-Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso
Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise fo..
Metal-Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles.
Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J Richardson, Frank Caruso
The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central ..
Oxidation-Mediated Kinetic Strategies for Engineering Metal-Phenolic Networks
Qi-Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso
The tunable growth of metal–organic materials has implications for engineering particles and surfaces for diverse applications. Sp..
Selective Metal-Phenolic Assembly from Complex Multicomponent Mixtures
Gan Lin, Md Arifur Rahim, Michael G Leeming, Christina Cortez-Jugo, Quinn A Besford, Yi Ju, Qi-Zhi Zhong, Stuart T Johnston, Jiajing Zhou, Frank Caruso
Selective self-assembly in multicomponent mixtures offers a method for isolating desired components from complex systems for the r..
Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films
Blaise L Tardy, Joseph J Richardson, Vichida Nithipipat, Kristian Kempe, Junling Guo, Kwun Lun Cho, Md Arifur Rahim, Hirotaka Ejima, Frank Caruso
Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabri..
Tuning the Mechanical Behavior of Metal-Phenolic Networks through Building Block Composition
Gyeongwon Yun, Joseph J Richardson, Matthew Biviano, Frank Caruso
Metal-phenolic networks (MPNs) are an emerging class of functional metal-organic materials with a high degree of modularity in ter..
Spray Assembly of Metal-Phenolic Networks: Formation, Growth, and Applications
Qi-Zhi Zhong, Shuaijun Pan, Md Arifur Rahim, Gyeongwon Yun, Jianhua Li, Yi Ju, Zhixing Lin, Yiyuan Han, Yutian Ma, Joseph J Richardson, Frank Caruso
Hybrid conformal coatings, such as metal-phenolic networks (MPNs) that are constructed from the coordination-driven assembly of na..
Supramolecular Metal-Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients
Md Arifur Rahim, Yuuki Hata, Mattias Bjornmalm, Yi Ju, Frank Caruso
The use of supramolecular gel media for the crystallization of active pharmaceutical ingredients (APIs) is of interest for control..