A novel mechanism for pathogen detection highly conserved in mammals

Grant number: DP170102471 | Funding period: 2017 - 2019

Completed

Abstract

This project aims to delineate biochemically how mammals fight pathogens by alerting their immune system to Vitamin B compounds produced by certain bacteria and fungi. The protein MR1 binds the compounds and displays them on the cell surface, activating pathogen-fighting MAIT cells. The MR1-MAIT cell axis is highly conserved in mammals and is thought to defend the host. This project expects to lead to new products to improve veterinary and human health services with new technology developed throughout the project and high-level training which will increase the competitiveness of the strategic biotechnology sector in Australia.

Related publications (8)

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Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

Caroline L Ashley, Brian P McSharry, Hamish EG McWilliam, Richard J Stanton, Ceri A Fielding, Rommel A Mathias, David P Fairlie, James McCluskey, Jose A Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman

2023-02-10

INTRODUCTION: The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to presen..

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A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells

Hui Jing Lim, Jacinta M Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey YW Mak, Abderrahman Hachani, Regan J Anderson, Gavin F Painter, Jesse Goyette, Shanika L Amarasinghe, Matthew E Ritchie, Antoine Roquilly, David P Fairlie, Katharina Gaus, Jamie Rossjohn, Jose A Villadangos, Hamish EG McWilliam

2022-09-21

MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B-related metabolite antigens from div..

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Unlocking autofluorescence in the era of full spectrum analysis: Implications for immunophenotype discovery projects

Vanta J Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K Mackay, Axel Kallies, Jose A Villadangos, Hamish EG McWilliam, Alexis Perez-Gonzalez

2022-04-12

Understanding the complex elements affecting signal resolution in cytometry is key for quality experimental design and data. In th..

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Differential antigen requirements by diverse MR1-restricted T cells (vol 100, pg 112, 2022)

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

2022-02-15

Correction to: Immunol Cell Biol 2022; 100: 112–126; https://doi.org/10.1111/imcb.12519 The authors omitted a grant from the Natio..

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Differential antigenic requirements by diverse MR1-restricted T cells

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

2022-01-13

MHC-related protein 1 (MR1) presents microbial riboflavin metabolites to mucosal-associated invariant T (MAIT) cells for surveilla..

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Varicella Zoster Virus Impairs Expression of the Nonclassical Major Histocompatibility Complex Class I-Related Gene Protein (MR1)

Shivam K Purohit, Carolyn Samer, Hamish EG McWilliam, Renee Traves, Megan Steain, Brian P McSharry, Paul R Kinchington, David C Tscharke, Jose A Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman

2021-11-24

The antigen presentation molecule MR1 (major histocompatibility complex, class I-related) presents ligands derived from the ribofl..

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Immune recognition of phosphoantigen-butyrophilin molecular complexes by gamma delta T cells

Adam P Uldrich, Marc Rigau, Dale I Godfrey

2020-10-05

Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhi..

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Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey

2020-07-10

The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..

University of Melbourne Researchers