Molecular and cellular regulation of ovarian development

Grant number: DP170100045 | Funding period: 2017 - 2019

Completed

Abstract

This project aims to understand cell fate decisions during ovarian development. While scientists understand the decision to differentiate into a male-specific cell type, they do not understand differentiation into female-specific cell types. This team has identified marker genes that distinguish between different female cell types in the developing ovary, and will analyse the molecular and cellular mechanisms that drive the development of the ovary. This could provide a deeper understanding of how genes influence cell fate decisions during embryogenesis, and the technologies developed here will be widely applicable in biotechnological research.

Related publications (5)

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Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries

Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-chung Hui, Dagmar Wilhelm, Joan S Jorgensen

2018-08-01

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Mutations in the HMGCS2 gene are associated with disorders of sex development

Stefan Bagheri-Fam, Michelle Wong, Sean Wilson, Katie Ayers, Raphael Rastetter, Paul Thomas, Serge Nef, Paulino Gomez-Puertas, Beatriz Puisac, Mar-A Hernandez-Marcos, Sergio Gil-Clavero, Juan Pie, Andrew Sinclair, Dagmar Wilhelm

2018-06-01

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Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary

M-C De Cian, E Pauper, R Bandiera, VPI Vidal, S Sacco, EP Gregoire, A-A Chassot, C Panzolini, D Wilhelm, E Pailhoux, SA Youssef, A de Bruin, K Teerds, A Schedl, I Gillot, M-C Chaboissier

2017-01-12

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WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary

Sonja E Gustin, Kirsten Hogg, Jessica M Stringer, Raphael H Rastetter, Emanuele Pelosi, Denise C Miles, Andrew H Sinclair, Dagmar Wilhelm, Patrick S Western

2016-04-15

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FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development

Zhilin Liu, Yi A Ren, Stephanie A Pangas, Jaye Adams, Wei Zhou, Diego H Castrillon, Dagmar Wilhelm, JoAnne S Richards

2015-07-01

Researchers