Molecular and cellular regulation of ovarian development

Grant number: DP170100045 | Funding period: 2017 - 2019

Completed

Abstract

This project aims to understand cell fate decisions during ovarian development. While scientists understand the decision to differentiate into a male-specific cell type, they do not understand differentiation into female-specific cell types. This team has identified marker genes that distinguish between different female cell types in the developing ovary, and will analyse the molecular and cellular mechanisms that drive the development of the ovary. This could provide a deeper understanding of how genes influence cell fate decisions during embryogenesis, and the technologies developed here will be widely applicable in biotechnological research.

Related publications (9)

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Heterozygous deletion of Sox9 in mouse mimics the gonadal sex reversal phenotype associated with campomelic dysplasia in humans

Stefan Bagheri-Fam, Alexander N Combes, Cheuk K Ling, Dagmar Wilhelm

2020-12-01

Heterozygous mutations in the human SOX9 gene cause the skeletal malformation syndrome campomelic dysplasia which in 75% of 46, XY..

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The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice.

Stefan Bagheri-Fam, Huijun Chen, Sean Wilson, Katie Ayers, James Hughes, Frederique Sloan-Bena, Pierre Calvel, Gorjana Robevska, Beatriz Puisac, Kamila Kusz-Zamelczyk, Stefania Gimelli, Anna Spik, Jadwiga Jaruzelska, Alina Warenik-Szymankiewicz, Sultana Faradz, Serge Nef, Juan Pié, Paul Thomas, Andrew Sinclair, Dagmar Wilhelm

2020-01-01

Disorders/differences of sex development (DSD) cause profound psychological and reproductive consequences for the affected individ..

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Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries

Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-chung Hui, Dagmar Wilhelm, Joan S Jorgensen

2018-08-01

Women and other mammalian females are born with a finite supply of oocytes that determine their reproductive lifespan. During feta..

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Mutations in the HMGCS2 gene are associated with disorders of sex development

Stefan Bagheri-Fam, Michelle Wong, Sean Wilson, Katie Ayers, Raphael Rastetter, Paul Thomas, Serge Nef, Paulino Gomez-Puertas, Beatriz Puisac, Mar-A Hernandez-Marcos, Sergio Gil-Clavero, Juan Pie, Andrew Sinclair, Dagmar Wilhelm

2018-06-01

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Genes and gene defects affecting gonadal development and sex determination

D Wilhelm, S Bagheri-Fam

2018-01-01

Sex in mammals is determined genetically with the acquisition of either the XX (female) or XY (male) chromosomes at the time of fe..

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Genetic mechanisms of sex determination

D Wilhelm, AJ Pask

2018-01-01

Sex determination, although crucially important for the survival of a species, is arguably the least conserved mechanism in evolut..

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Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary

M-C De Cian, E Pauper, R Bandiera, VPI Vidal, S Sacco, EP Gregoire, A-A Chassot, C Panzolini, D Wilhelm, E Pailhoux, SA Youssef, A de Bruin, K Teerds, A Schedl, I Gillot, M-C Chaboissier

2017-01-12

R-spondin1 is a secreted regulator of WNT signaling, involved in both embryonic development and homeostasis of adult organs. It ca..

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WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary

Sonja E Gustin, Kirsten Hogg, Jessica M Stringer, Raphael H Rastetter, Emanuele Pelosi, Denise C Miles, Andrew H Sinclair, Dagmar Wilhelm, Patrick S Western

2016-04-15

Sexual development is initiated through differentiation of testicular Sertoli cells or ovarian granulosa cells. Although these sup..

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FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development

Zhilin Liu, Yi A Ren, Stephanie A Pangas, Jaye Adams, Wei Zhou, Diego H Castrillon, Dagmar Wilhelm, JoAnne S Richards

2015-07-01

The forkhead box (FOX), FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivat..

University of Melbourne Researchers