Mathematical and statistical methods for modelling invivo pathogen dynamics
Grant number: DP170103076 | Funding period: 2017 - 2020
This project aims to develop mathematical models and Bayesian statistical methods that better capture how natural defence responses and drugs help control infection. When viruses (e.g. influenza) or parasites (e.g. malaria) invade the human body, they begin to replicate. To date, only simple mathematical models have been developed to capture these processes, and these models are not well formulated. This project will improve biomathematics and biostatistical algorithms for pathogen dynamics and is ultimately expected to benefit public health and clinical research aimed at alleviating the effect of infectious diseases on human health.
Related publications (13)
The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study
Saber Dini, Nicholas M Douglas, Jeanne Rini Poespoprodjo, Enny Kenangalem, Paulus Sugiarto, Ian D Plumb, Ric N Price, Julie A Simpson
BACKGROUND: An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence o..
Modelling the population dynamics of Plasmodium falciparum gametocytes in humans during malaria infection
Pengxing Cao, Katharine Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie Simpson, James McCarthy, James McCaw
Every year over two hundred million people are infected with the malaria parasite. Renewed efforts to eliminate malaria has highli..
Sequential infection experiments for quantifying innate and adaptive immunity during influenza infection
Ada WC Yan, Sophie G Zaloumis, Julie A Simpson, James M McCaw
Laboratory models are often used to understand the interaction of related pathogens via host immunity. For example, recent experim..
Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling
Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson
The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an..
Within-host modeling of blood-stage malaria
David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport
Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..
A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw
Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light ..