NOVEL APPROACHES TO THE PREVENTION AND TREATMENT OF CHRONIC HEART DISEASE AND ITS CO-MORBID COMPLICATIONS

Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings

Cindy Nguyen, Amanda J Edgley, Darren J Kelly, Andrew R Kompa

2022-02-01

The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to contribute towards progressive cardio..

NP202 treatment improves left ventricular systolic function and attenuates pathological remodelling following chronic myocardial infarction

Andrew R Kompa, Fay L Khong, Yuan Zhang, Cindy Nguyen, Amanda J Edgley, Owen L Woodman, Grant McLachlan, Darren J Kelly

2021-12-15

AIMS: Myocardial injury is a major contributor to left ventricular (LV) remodelling activating neurohormonal and inflammatory proc..

Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition

Feby Savira, Ruth Magaye, Carmen Scullino, Bernard L Flynn, Stuart M Pitson, Dovile Anderson, Darren J Creek, Yue Hua, Xin Xiong, Li Huang, Danny Liew, Christopher Reid, David Kaye, Andrew R Kompa, Bing Hui Wang

2021-07-24

Non-dialysable protein-bound uremic toxins (PBUTs) contribute to the development of cardiovascular disease (CVD) in chronic kidney..

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGF beta induced collagen synthesis in cardiac fibroblasts

Ruth R Magaye, Feby Savira, Xin Xiong, Kevin Huynh, Peter J Meikle, Christopher Reid, Bernard L Flynn, David Kaye, Danny Liew, Bing H Wang

2021-07-06

The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being..

The role of CHA(2)DS(2)-VASc score in evaluating patients with atrial fibrillation undergoing percutaneous coronary intervention

Shane Parfrey, Andrew W Teh, Louise Roberts, Angela Brennan, David Clark, Stephen J Duffy, Andrew E Ajani, Christopher M Reid, Melanie Freeman

2021-06-01

OBJECTIVE: The aim of the review was to assess whether CHA2DS2-VASc score is predictive of mortality in patients with atrial fibri..

Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects

Feby Savira, Andrew R Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

2021-02-24

AIMS: Indoxyl sulfate (IS), a protein-bound uremic toxin, is implicated in endothelial dysfunction, which contributes to adverse c..

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

2021-02-08

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

Feby Savira, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa, Bing H Wang

2021-01-15

beta-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

2021-01-01

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitro..

Effect of Aspirin vs Placebo on the Prevention of Depression in Older People A Randomized Clinical Trial

Michael Berk, Robyn L Woods, Mark R Nelson, Raj C Shah, Christopher M Reid, Elsdon Storey, Sharyn Fitzgerald, Jessica E Lockery, Rory Wolfe, Mohammadreza Mohebbi, Seetal Dodd, Anne M Murray, Nigel Stocks, Paul B Fitzgerald, Catherine Mazza, Bruno Agustini, John J McNeil

2020-10-01

IMPORTANCE: Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some pr..

RE: ASK1, a new target in treating cardiorenal syndrome (CRS)

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

2020-10-01

Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1.

Ruth R Magaye, Feby Savira, Yue Hua, Xin Xiong, Li Huang, Christopher Reid, Bernard Flynn, David Kaye, Danny Liew, Bing H Wang

2020-08-01

Cardiac fibrosis and myocyte hypertrophy are hallmarks of the cardiac remodelling process in cardiomyopathies such as heart failur..

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa

2020-07-01

BACKGROUND: Cardiorenal syndrome (CRS) is a major health burden worldwide in need of novel therapies, as current treatments remain..

Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature

Feby Savira, Ruth Magaye, Danny Liew, Christopher Reid, Darren J Kelly, Andrew R Kompa, S Jeson Sangaralingham, John C Burnett, David Kaye, Bing H Wang

2020-05-13

Cardiorenal syndrome (CRS) is a multi-organ disease, encompassing heart, kidney and vascular system dysfunction. CRS is a worldwid..

Structured Feedback: Acceptability and Feasibility of a Strategy to Enhance the Role of a Clinical Quality Registry to Drive Change in Cardiac Surgical Practice

Nupur Nag, Lavinia Tran, Kathy Fotis, Julian A Smith, Gilbert C Shardey, Robert A Baker, Christopher M Reid

2019-08-01

BACKGROUND: The Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) Database collects and monitors preop..

Temporal Changes in Characteristics, Treatment and Outcomes of Heart Failure Patients Undergoing Percutaneous Coronary Intervention Findings From Melbourne Interventional Group Registry

Ken Lee Chin, Mark Tacey, Christopher M Reid, Andrew Tonkin, Ingrid Hopper, Angela Brennan, Nick Andrianopoulos, Stephen J Duffy, David Clark, Andrew E Ajani, Danny Liew

2019-07-01

BACKGROUND: Limited data exist on whether outcomes of patients with heart failure (HF) undergoing percutaneous coronary interventi..

Molecular mechanisms of protein-bound uremic toxin-mediated cardiac, renal and vascular effects: underpinning intracellular targets for cardiorenal syndrome therapy

Feby Savira, Ruth Magaye, Yue Hua, Danny Liew, David Kaye, Tom Marwick, Bing Hui Wang

2019-06-15

Cardiorenal syndrome (CRS) remains a global health burden with a lack of definitive and effective treatment. Protein-bound uremic ..

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

Wendi Yang, Bing Hui Wang, Ian Wang, Li Huang, Feby Savira, Andrew Kompa, Beat M Jucker, Robert N Willette, Darren Kelly, Henry Krum, Zhiliang Li, Qian Fu

2019-03-01

BACKGROUND: Cardiac remodelling is a dynamic process whereby structural and functional changes occur within the heart in response ..

The role of dihydrosphingolipids in disease

Ruth R Magaye, Feby Savira, Yue Hua, Darren J Kelly, Christopher Reid, Bernard Flynn, Danny Liew, Bing H Wang

2019-03-01

Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sp..

The Challenges of Stem Cell Therapy in Myocardial Infarction and Heart Failure and the Potential Strategies to Improve the Outcomes

Bing Hui Wang, Danny Liew, Kevin W Huang, Li Huang, Wenjie Tang, Darren J Kelly, Christopher Reid, Zhongmin Liu

2018-12-01

<jats:p> Cardiovascular disease remains the single highest global cause of death and a significant financial burden on the healthc..

Relation of Alcohol Consumption to Risk of Heart Failure in Patients Aged 65 to 84 Years With Hypertension

Berhe W Sahle, Alice J Owen, Lindon MH Wing, Lawrence J Beilin, Mark R Nelson, Garry LR Jennings, Christopher M Reid

2018-10-15

Although a high level of alcohol consumption is associated with cardiomyopathy, the benefit or risk of moderate alcohol consumptio..

Cost-Effectiveness of Rena Denervation Therapy for Treatment-Resistant Hypertension: A Best Case Scenario

Enayet Karim Chowdhury, Christopher M Reid, Ella Zomer, Darren J Kelly, Danny Liew

2018-10-01

BACKGROUND: Renal denervation (RDN) is effective at reducing blood pressure (BP) among patients with treatment-resistant hypertens..

Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis - the RESTORE trial protocol

Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell

2018-07-28

BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure ..

Angiotensin receptor neprilysin inhibition provides superior cardioprotection compared to angiotensin converting enzyme inhibition after experimental myocardial infarction

Andrew R Kompa, Jiayu Lu, Thomas J Weller, Darren J Kelly, Henry Krum, Thomas G von Lueder, Bing H Wang

2018-05-01

BACKGROUND: Angiotensin receptor neprilysin inhibitor (ARNi) enhances beneficial natriuretic peptides by inhibiting their breakdow..

Cardiac fibrosis in the ageing heart: Contributors and mechanisms

Lu Lu, Jingbin Guo, Yue Hua, Kevin Huang, Ruth Magaye, Jake Cornell, Darren J Kelly, Christopher Reid, Danny Liew, Yingchun Zhou, Aihua Chen, Wei Xiao, Qiang Fu, Bing Hui Wang

2017-12-01

Cardiac fibrosis refers to an excessive deposition of extracellular matrix (ECM) in cardiac tissue. Fibrotic tissue is stiffer and..

Long-term survival following the development of heart failure in an elderly hypertensive population

Berhe W Sahle, Alice J Owen, Lindon MH Wing, Lawrence J Beilin, Henry Krum, Christopher M Reid

2017-12-01

BACKGROUND: Available data on the prognosis of heart failure (HF) patients are predominantly limited to patients diagnosed at time..

Risk Prediction Models for Incident Heart Failure: A Systematic Review of Methodology and Model Performance

Berhe W Sahle, Alice J Owen, Ken Lee Chin, Christopher M Reid

2017-09-01

BACKGROUND: Numerous models predicting the risk of incident heart failure (HF) have been developed; however, evidence of their met..

ASPREE-D: Aspirin for the prevention of depression in the elderly

Michael Berk, RL Woods, MR Nelson, RC Shah, CM Reid, E Storey, SM Fitzgerald, JE Lockery, R Wolfe, M Mohebbi, AM Murray, B Kirpach, R Grimm, JJ McNeil

2016-10-01

BACKGROUND: Not only is depression associated with increased inflammation but inflammation is a risk factor for the genesis of dep..

Do p38 mitogen-activated protein kinase inhibitors have a future for the treatment of cardiovascular disease?

Andrew R Kompa

2016-09-01

Prevalence of heart failure in Australia: a systematic review

Berhe W Sahle, Alice J Owen, Mutsa P Mutowo, Henry Krum, Christopher M Reid

2016-02-06

BACKGROUND: In the absence of a systematic collection of data pertaining to heart failure, summarizing the data available from ind..