DISSECTING THE CENTRAL ORGANISATION OF COUGH NEURAL NETWORKS

Modulation of Vagal Sensory Neurons via High Mobility Group Box-1 and Receptor for Advanced Glycation End Products: Implications for Respiratory Viral Infections

Stuart B Mazzone, Seung-Kwon Yang, Jennifer A Keller, Juste Simanauskaite, Jaisy Arikkatt, Matthew J Fogarty, Aung Aung Kywe Moe, Chen Chen, Matthew W Trewella, Luyi Tian, Matthew E Ritchie, Brendan Y Chua, Simon Phipps, Kirsty R Short, Alice E McGovern

2021-09-21

Vagal sensory neurons contribute to the symptoms and pathogenesis of inflammatory pulmonary diseases through processes that involv..

Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat

Pedro Trevizan-Bau, Werner Furuya, Stuart B Mazzone, Davor Stanic, Rishi R Dhingra, Mathias Dutschmann

2021-02-18

Synaptic activities of the periaqueductal gray (PAG) can modulate or appropriate the respiratory motor activities in the context o..

Forebrain projection neurons target functionally diverse respiratory control areas in the midbrain, pons, and medulla oblongata

Pedro Trevizan-Bau, Rishi R Dhingra, Werner I Furuya, Davor Stanic, Stuart B Mazzone, Mathias Dutschmann

2021-01-05

Eupnea is generated by neural circuits located in the ponto-medullary brainstem, but can be modulated by higher brain inputs which..

Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus

Stuart B Mazzone, Tara G Bautista, Anthony JM Verberne, Matthew W Trewella, Michael J Farrell, Alice E McGovern

2020-12-02

The nodose and jugular vagal ganglia supply sensory innervation to the airways and lungs. Jugular vagal airway sensory neurons wir..

Evidence for multiple bulbar and higher brain circuits processing sensory inputs from the respiratory system in humans

Michael J Farrell, Tara G Bautista, Emma Liang, Damian Azzollini, Gary F Egan, Stuart B Mazzone

2020-10-07

KEY POINTS: Unpleasant respiratory sensations contribute to morbidity in pulmonary disease. In rodents, these sensations are proce..

A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs

Alexandria K Driessen, Alice E McGovern, Robert Behrens, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

2020-05-01

KEY POINTS: Airway projecting sensory neurons arising from the jugular vagal ganglia terminate centrally in the brainstem paratrig..

Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons

Stuart B Mazzone, Luyi Tian, Aung Aung Kywe Moe, Matthew W Trewella, Matthew E Ritchie, Alice E McGovern

2019-10-19

Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chem..

Altered neural activity in brain cough suppression networks in cigarette smokers

Ayaka Ando, Stuart B Mazzone, Michael J Farrell

2019-09-01

Cough is important for airway defence, and studies in healthy animals and humans have revealed multiple brain networks intimately ..

Are neural pathways processing airway inputs sensitized in patients with cough hypersensitivity?

Michael J Farrell, Stuart B Mazzone

2019-08-01

Patients with cough hypersensitivity exhibit unusually low thresholds for responses to tussive stimuli, exaggerated responses to s..

Heterogeneity of cough neurobiology: Clinical implications

Stuart B Mazzone, Michael J Farrell

2019-04-01

Cough is an important protective mechanism for clearing the airways but becomes a troublesome, and often difficult to treat, sympt..

Regional brain stem activations during capsaicin inhalation using functional magnetic resonance imaging in humans

Tara G Bautista, Jennifer Leech, Stuart B Mazzone, Michael J Farrell

2019-04-01

Coughing is an airway protective behavior elicited by airway irritation. Animal studies show that airway sensory information is re..

Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits

Alexandria K Driessen, Michael J Farrell, Mathias Dutschmann, Davor Stanic, Alice E McGovern, Stuart B Mazzone

2018-12-01

Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to the poorly studied medullary paratrige..

Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets

Alice E McGovern, Kirsty R Short, Aung Aung Kywe Moe, Stuart B Mazzone

2018-11-01

Cough is an essential defensive behavior for maintaining airway patency and to protect the lungs from potentially harmful agents. ..

Hippocampal modulation of cardiorespiratory function

Itopa E Ajayi, Alice E McGovern, Alexandria K Driessen, Nicole F Kerr, Paul C Mills, Stuart B Mazzone

2018-06-01

Changes in cardiorespiratory control accompany the expression of complex emotions, indicative of limbic brain inputs onto bulbar a..

Central mechanisms of airway sensation and cough hypersensitivity

Alexandria K Driessen, Alice E McGovern, Monica Narula, Seung-Kwon Yang, Jennifer A Keller, Michael J Farrell, Stuart B Mazzone

2017-12-01

The airway sensory nervous system is composed of two anatomically distinct processing pathways that allow for the production of re..

A neuroanatomical framework for the central modulation of respiratory sensory processing and cough by the periaqueductal grey

Alice E McGovern, Itopa E Ajayi, Michael J Farrell, Stuart B Mazzone

2017-10-01

Sensory information arising from the airways is processed in a distributed brain network that encodes for the discriminative and a..

Translating Cough Mechanisms Into Better Cough Suppressants

Jennifer A Keller, Alice E McGovern, Stuart B Mazzone

2017-10-01

Chronic cough is a significant problem, and in many patients cough remains refractive to both disease-specific therapies and curre..

VAGAL AFFERENT INNERVATION OF THE AIRWAYS IN HEALTH AND DISEASE

Stuart B Mazzone, Bradley J Undem

2016-07-01

Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their emb..

Multiple neural circuits mediating airway sensations: Recent advances in the neurobiology of the urge-to-cough

Alexandria K Driessen, Michael J Farrell, Stuart B Mazzone, Alice E McGovern

2016-06-01

The respiratory system is densely innervated by sensory neurons arising from the jugular (superior) and nodose (inferior) vagal ga..

Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control

Ayaka Ando, David Smallwood, Marcus McMahon, Louis Irving, Stuart B Mazzone, Michael J Farrell

2016-04-01

INTRODUCTION: Chronic non-productive coughing is a major complication of pulmonary disease and can also occur in many individuals ..

The Role of the Paratrigeminal Nucleus in Vagal Afferent Evoked Respiratory Reflexes: A Neuroanatomical and Functional Study in Guinea Pigs

Alexandria K Driessen, Michael J Farrell, Stuart B Mazzone, Alice E McGovern

2015-12-21

The respiratory tree receives sensory innervation from the jugular and nodose vagal sensory ganglia. Neurons of these ganglia are ..

Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity

Bradley J Undem, Eric Zaccone, Lorcan McGarvey, Stuart B Mazzone

2015-08-01

Respiratory viral infections are a common cause of acute coughing, an irritating symptom for the patient and an important mechanis..

Endogenous central suppressive mechanisms regulating cough as potential targets for novel antitussive therapies

Stuart B Mazzone, Alice E McGovern, Michael J Farrell

2015-06-01

Cough and the accompanying sensation known as the urge-to-cough are complex neurobiological phenomena dependent on sensory and mot..

Distinct Brainstem and Forebrain Circuits Receiving Tracheal Sensory Neuron Inputs Revealed Using a Novel Conditional Anterograde Transsynaptic Viral Tracing System

Alice E McGovern, Alexandria K Driessen, David G Simmons, Joseph Powell, Nicholas Davis-Poynter, Michael J Farrell, Stuart B Mazzone

2015-05-06

Sensory nerves innervating the mucosa of the airways monitor the local environment for the presence of irritant stimuli and, when ..