IMPROVING PERINATAL OUTCOMES
Grant number: 1113902 | Funding period: 2017 - 2023
The exposure of infants to adverse events both before and after birth can cause death or permanent disability (eg cerebral palsy) for the infant. Our primary research objective is to minimize the impact and improve outcomes for infants exposed to adverse events before and/or after birth. We will use a multi-disciplinary approach that aims to understand the science and to develop new treatments, thereby representing true “bench to bedside” research.
Related publications (20)
Silencing of Nrf genes in the human placenta as measured by SDS-PAGE and Western Blotting techniques
Yann W Yap, Natalie J Hannan, Euan M Wallace, Sarah A Marshall
Nuclear factor erythroid 2-related factor-2 (Nrf2), and the less well characterised proteins Nrf1 and Nrf3, are member of the cap ..
Effects of tactile stimulation on spontaneous breathing during face mask ventilation
Vincent D Gaertner, Christoph Martin Rueegger, Dirk Bassler, Eoin O'Currain, C Omar Farouk Kamlin, Stuart B Hooper, Peter G Davis, Laila Springer
OBJECTIVE: We sought to determine the effect of stimulation during positive pressure ventilation (PPV) on the number of spontaneou..
Time to desaturation in preterm infants undergoing endotracheal intubation
Radhika Kothari, Kate Alison Hodgson, Peter G Davis, Marta Thio, Brett James Manley, Eoin O'Currain
BACKGROUND: Neonatal endotracheal intubation is often associated with physiological instability. The Neonatal Resuscitation Progra..
Physiological responses to facemask application in newborns immediately after birth
Vincent D Gaertner, Christoph Martin Ruegger, Eoin O'Currain, C Omar Farouk Kamlin, Stuart B Hooper, Peter G Davis, Laila Springer
OBJECTIVE: Application of a face mask may induce apnoea and bradycardia, possibly via the trigeminocardiac reflex (TCR). We aimed ..
Observational study of parental opinion of deferred consent for neonatal research
Samantha Sloss, Jennifer Anne Dawson, Lorraine McGrory, Anthony Richard Rafferty, Peter G Davis, Louise S Owen
OBJECTIVE: To evaluate the opinions of parents of newborns following their infant's enrolment into a neonatal research study throu..
Preventing critical failure. Can routinely collected data be repurposed to predict avoidable patient harm? A quantitative descriptive study.
Benjamin Michael Nowotny, Miranda Davies-Tuck, Belinda Scott, Michael Stewart, Elizabeth Cox, Karen Cusack, Martin Fletcher, Eva Saar, Tanya Farrell, Shirin Anil, Louise McKinlay, Euan M Wallace
OBJECTIVES: To determine whether sharing of routinely collected health service performance data could have predicted a critical sa..
Corrigendum to "Sulforaphane improves syncytiotrophoblast mitochondrial function after in vitro hypoxic and superoxide injury" [Placenta 96 (2020) 44-54].
A Langston-Cox, AM Muccini, SA Marshall, Y Yap, KR Palmer, EM Wallace, SJ Ellery
The authors regret omission of funding bodies from the acknowledgements section of this manuscript. This research was funded by th..
Interfaces for non-invasive neonatal resuscitation in the delivery room: A systematic review and meta-analysis
Smitha Machumpurath, Eoin O'Currain, Jennifer A Dawson, Peter G Davis
OBJECTIVE: To perform a systematic review of trials comparing interfaces for delivering non-invasive PPV to a newborn in the deliv..
Sulforaphane improves syncytiotrophoblast mitochondrial function after in vitro hypoxic and superoxide injury.
A Langston-Cox, AM Muccini, SA Marshall, null Yap, KR Palmer, EM Wallace, SJ Ellery
INTRODUCTION: Placental mitochondrial dysfunction contributes to the oxidative stress that underlies preeclampsia. Here, we assess..
Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method
Annie Langston-Cox, Dovile Anderson, Darren J Creek, Kirsten Palmer, Euan M Wallace, Sarah A Marshall
(1) Background: There is increasing understanding of the potential health benefits of cruciferous vegetables. In particular sulfor..
A multicentre, randomised trial of stabilisation with nasal high flow during neonatal endotracheal intubation (the SHINE trial): a study protocol
Kate A Hodgson, Louise S Owen, Camille Omar Kamlin, Calum T Roberts, Susan M Donath, Peter G Davis, Brett James Manley
INTRODUCTION: Neonatal endotracheal intubation is an essential but potentially destabilising procedure. With an increased focus on..
Respiratory monitors to teach newborn facemask ventilation: a randomised trial
Eoin O'Currain, Marta Thio, Jennifer Anne Dawson, Susan M Donath, Peter G Davis
OBJECTIVE: The International Liaison Committee on Resuscitation has found that there is a need for high-quality randomised trials ..
The effect of smell and taste of milk during tube feeding of preterm infants (the Taste trial): a protocol for a randomised controlled trial
Friederike Beker, Judith Macey, Helen Liley, Ian Hughes, Peter G Davis, Emily Twitchell, Susan Jacobs
INTRODUCTION: Smell and taste of milk are not generally considered when tube feeding preterm infants. Preterm infants have rapid g..
Human amnion cells for the prevention of bronchopulmonary dysplasia: a protocol for a phase I dose escalation study
Elizabeth Kate Baker, Atul Malhotra, Rebecca Lim, Susan E Jacobs, Stuart B Hooper, Peter G Davis, Euan M Wallace
INTRODUCTION: Bronchopulmonary dysplasia (BPD), an important sequela of preterm birth, is associated with long-term abnormalities ..
Smaller facemasks for positive pressure ventilation in preterm infants: A randomised trial
Eoin O'Currain, Joyce E O'Shea, Lorraine McGrory, Louise S Owen, Omar Kamlin, Jennifer A Dawson, Peter G Davis, Marta Thio
AIM: Facial measurements of preterm infants indicate that standard diameter facemasks used during positive pressure ventilation ar..