IMPROVING PERINATAL OUTCOMES

Grant number: 1113902 | Funding period: 2017 - 2023

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Abstract

The exposure of infants to adverse events both before and after birth can cause death or permanent disability (eg cerebral palsy) for the infant. Our primary research objective is to minimize the impact and improve outcomes for infants exposed to adverse events before and/or after birth. We will use a multi-disciplinary approach that aims to understand the science and to develop new treatments, thereby representing true “bench to bedside” research.

Related publications (20)

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Silencing of Nrf genes in the human placenta as measured by SDS-PAGE and Western Blotting techniques

Yann W Yap, Natalie J Hannan, Euan M Wallace, Sarah A Marshall

2022-01-16

Nuclear factor erythroid 2-related factor-2 (Nrf2), and the less well characterised proteins Nrf1 and Nrf3, are member of the cap ..

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Effects of tactile stimulation on spontaneous breathing during face mask ventilation

Vincent D Gaertner, Christoph Martin Rueegger, Dirk Bassler, Eoin O'Currain, C Omar Farouk Kamlin, Stuart B Hooper, Peter G Davis, Laila Springer

2021-12-02

OBJECTIVE: We sought to determine the effect of stimulation during positive pressure ventilation (PPV) on the number of spontaneou..

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Time to desaturation in preterm infants undergoing endotracheal intubation

Radhika Kothari, Kate Alison Hodgson, Peter G Davis, Marta Thio, Brett James Manley, Eoin O'Currain

2021-11-01

BACKGROUND: Neonatal endotracheal intubation is often associated with physiological instability. The Neonatal Resuscitation Progra..

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The SHINE trial (a multicentre, randomised trial of stabilisation with nasal high flow during neonatal endotracheal intubation): statistical analysis plan

Kate Hodgson, Brett Manley, Omar Kamlin, Louise Owen, Calum Roberts, Kate Francis, Peter Davis, Susan Donath

2021-08-24

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Physiological responses to facemask application in newborns immediately after birth

Vincent D Gaertner, Christoph Martin Ruegger, Eoin O'Currain, C Omar Farouk Kamlin, Stuart B Hooper, Peter G Davis, Laila Springer

2021-07-01

OBJECTIVE: Application of a face mask may induce apnoea and bradycardia, possibly via the trigeminocardiac reflex (TCR). We aimed ..

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Observational study of parental opinion of deferred consent for neonatal research

Samantha Sloss, Jennifer Anne Dawson, Lorraine McGrory, Anthony Richard Rafferty, Peter G Davis, Louise S Owen

2021-05-01

OBJECTIVE: To evaluate the opinions of parents of newborns following their infant's enrolment into a neonatal research study throu..

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Parental consent and neonatal delivery room trials: walking an ethical tightrope.

Louise S Owen, Peter G Davis

2021-03-01

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Preventing critical failure. Can routinely collected data be repurposed to predict avoidable patient harm? A quantitative descriptive study.

Benjamin Michael Nowotny, Miranda Davies-Tuck, Belinda Scott, Michael Stewart, Elizabeth Cox, Karen Cusack, Martin Fletcher, Eva Saar, Tanya Farrell, Shirin Anil, Louise McKinlay, Euan M Wallace

2021-03-01

OBJECTIVES: To determine whether sharing of routinely collected health service performance data could have predicted a critical sa..

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Corrigendum to "Sulforaphane improves syncytiotrophoblast mitochondrial function after in vitro hypoxic and superoxide injury" [Placenta 96 (2020) 44-54].

A Langston-Cox, AM Muccini, SA Marshall, Y Yap, KR Palmer, EM Wallace, SJ Ellery

2020-11-01

The authors regret omission of funding bodies from the acknowledgements section of this manuscript. This research was funded by th..

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Interfaces for non-invasive neonatal resuscitation in the delivery room: A systematic review and meta-analysis

Smitha Machumpurath, Eoin O'Currain, Jennifer A Dawson, Peter G Davis

2020-11-01

OBJECTIVE: To perform a systematic review of trials comparing interfaces for delivering non-invasive PPV to a newborn in the deliv..

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Sulforaphane improves syncytiotrophoblast mitochondrial function after in vitro hypoxic and superoxide injury.

A Langston-Cox, AM Muccini, SA Marshall, null Yap, KR Palmer, EM Wallace, SJ Ellery

2020-07-01

INTRODUCTION: Placental mitochondrial dysfunction contributes to the oxidative stress that underlies preeclampsia. Here, we assess..

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Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method

Annie Langston-Cox, Dovile Anderson, Darren J Creek, Kirsten Palmer, Euan M Wallace, Sarah A Marshall

2020-02-02

(1) Background: There is increasing understanding of the potential health benefits of cruciferous vegetables. In particular sulfor..

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A multicentre, randomised trial of stabilisation with nasal high flow during neonatal endotracheal intubation (the SHINE trial): a study protocol

Kate A Hodgson, Louise S Owen, Camille Omar Kamlin, Calum T Roberts, Susan M Donath, Peter G Davis, Brett James Manley

2020-01-01

INTRODUCTION: Neonatal endotracheal intubation is an essential but potentially destabilising procedure. With an increased focus on..

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Delivery room emergencies: Respiratory emergencies in the DR

Louise S Owen, Brett J Manley, Peter G Davis

2019-12-01

The majority of newborns transition to extra uterine life without support. However, respiratory emergencies in the delivery room a..

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Changes in the modes of twin birth in Victoria, 1983-2015

Yizhen Amy Liu, Mary-Ann Davey, Rilka Lee, Kirsten R Palmer, Euan M Wallace

2019-11-12

OBJECTIVES: To examine changes in the modes of delivery of twins in Victoria over 33 years. DESIGN: Retrospective population-based..

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Compromised pressure and flow during suction mask ventilation

Christoph Martin Ruegger, Eoin O'Currain, Jennifer Anne Dawson, Peter G Davis, Camille Omar Farouk Kamlin, Laila Lorenz

2019-11-01

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Respiratory monitors to teach newborn facemask ventilation: a randomised trial

Eoin O'Currain, Marta Thio, Jennifer Anne Dawson, Susan M Donath, Peter G Davis

2019-11-01

OBJECTIVE: The International Liaison Committee on Resuscitation has found that there is a need for high-quality randomised trials ..

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The effect of smell and taste of milk during tube feeding of preterm infants (the Taste trial): a protocol for a randomised controlled trial

Friederike Beker, Judith Macey, Helen Liley, Ian Hughes, Peter G Davis, Emily Twitchell, Susan Jacobs

2019-08-01

INTRODUCTION: Smell and taste of milk are not generally considered when tube feeding preterm infants. Preterm infants have rapid g..

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Human amnion cells for the prevention of bronchopulmonary dysplasia: a protocol for a phase I dose escalation study

Elizabeth Kate Baker, Atul Malhotra, Rebecca Lim, Susan E Jacobs, Stuart B Hooper, Peter G Davis, Euan M Wallace

2019-06-01

INTRODUCTION: Bronchopulmonary dysplasia (BPD), an important sequela of preterm birth, is associated with long-term abnormalities ..

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Smaller facemasks for positive pressure ventilation in preterm infants: A randomised trial

Eoin O'Currain, Joyce E O'Shea, Lorraine McGrory, Louise S Owen, Omar Kamlin, Jennifer A Dawson, Peter G Davis, Marta Thio

2019-01-01

AIM: Facial measurements of preterm infants indicate that standard diameter facemasks used during positive pressure ventilation ar..