Traceback - Identification of Women Carrying Germline Brca1/2 Mutations Through a Retrospective Analysis of Patients Diagnosed With High Grade Serous Ovarian Cancer

Grant number: 1133906 | Funding period: 2017 - 2019

Completed

Abstract

Inheriting a mutated-BRCA is associated with significant risk of developing cancer. It is a crucial diagnosis to make with proven procedures that can reduce the risk of cancer developing. Ovarian cancer (HGSOC) is the tumour most strongly associated with BRCA (15-20%) and provides a diagnostic opportunity, but despite Australian guidelines

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Using polygenic risk scores to refine risk and outcomes in high-grade serous ovarian cancer in Australia.

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BACKGROUND: Ovarian cancer is characterised by high mortality and lacks effective screening, making prevention critical. Polygenic..

TRACEBACK: Testing of Historical Tubo-Ovarian Cancer Patients for Hereditary Risk Genes as a Cancer Prevention Strategy in Family Members

R Delahunty, L Nguyen, S Craig, B Creighton, D Ariyaratne, DW Garsed, E Christie, S Fereday, L Andrews, A Lewis, S Limb, A Pandey, J Hendley, N Traficante, N Carvajal, AB Spurdle, B Thompson, MT Parsons, V Beshay, M Volcheck

2022-06-20

PURPOSETubo-ovarian cancer (TOC) is a sentinel cancer for BRCA1 and BRCA2 pathogenic variants (PVs). Identification of a PV in the..

University of Melbourne Researchers

Prof David Bowtell