A STRUCTURAL, CHEMICAL AND FUNCTIONAL INVESTIGATION INTO MAIT CELL RECEPTOR RECOGNITION

Grant number: 1125493 | Funding period: 2017 - 2020

Completed

Abstract

This project is focused on a type of T-cell, termed a MAIT cell, which is found abundantly in the lining of the gut. We are investigating how this MAIT cell is activated by riboflavin and folic acid metabolites. We are also examining how commonly prescribed drugs impact MAIT cells and how such activation may be linked to diseases, including inflammatory bowel disease.

University of Melbourne Researchers