A NOVEL ROLE FOR PROTEOLYSIS IN PROMOTING INNER EAR CELL INJURY AND HEARING LOSS

Grant number: 1125376 | Funding period: 2017 - 2021

Completed

Abstract

Nearly 40% of hearing loss is attributable to traumatic noise exposure. This project will test a new idea that cells in the inner ear are damaged and die via noise-induced proteolysis, and investigate whether a similar mechanism operates during age-related hearing loss. It will open new avenues for therapies to preserve hearing where trauma is unavoidable, or has occurred through accident or incident.

University of Melbourne Researchers