BUILDING AN IMMUNOCOMPETENT ALZHEIMER'S DISEASE BRAIN-ON-A-CHIP

Abstract

New human cell culture models of Alzheimer's disease are urgently needed to help translate drugs into successful patient outcomes. In this proposal we will develop an Alzheimer's disease brain-on-a-chip that contains the major human brain cell types and neuropathological features of the Alzheimer's. We will demonstrate the applicability of the model for identifying new Alzheimer's disease drugs and diagnostics and show that the model can be readily adopted by Australian Alzheimer's researchers.