THE ROLE OF REDUCED PHAGOCYTOSIS IN THE PATHOGENESIS OF AGE-RELATED MACULAR DEGENERATION
Grant number: 1120095 | Funding period: 2017 - 2019
Completed
Abstract
Understanding the underlying mechanisms which lead to age-related macular degeneration (AMD) is critical if we are to ultimately develop novel treatments. We hypothesise that there is a defective ability to remove debris that accumulates in the retina as we age and this is a crucial step in the development of AMD. We will investigate this hypothesis in an AMD cohort and in a pre-clinical model where we will test the efficacy of an intervention that improves the ability to clear debris.