TARGETING OXIDANT-DEPENDENT PATHWAYS TO IMPROVE STROKE OUTCOMES IN COPD
Grant number: 1120522 | Funding period: 2017 - 2020
Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th largest cause of death worldwide. Patients with COPD are at increased risk for stroke and this is even higher in the weeks following a lung viral infection. The reason for this is unknown so the aim of this study is to determine why people with COPD are at increased risk for stroke and then develop novel treatments to prevent or reduce stroke in COPD patients.
Related publications (6)
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice
Kurt Brassington, Stanley MH Chan, Simone N De Luca, Aleksandar Dobric, Suleman A Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos
People with chronic obstructive pulmonary disease (COPD) are susceptible to respiratory infections which exacerbate pulmonary and/..
Ebselen reduces cigarette smoke-induced vascular endothelial dysfunction in mice
Kurt Brassington, Stanley MH Chan, Huei Jiunn Seow, Aleksandar Dobric, Steven Bozinovski, Stavros Selemidis, Ross Vlahos
BACKGROUND AND PURPOSE: It is well established that both smokers and patients with COPD are at a significantly heightened risk of ..
Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation
Ashton Bernard, Jacqueline M Ku, Ross Vlahos, Alyson A Miller
Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies have shown that cigarette smoke e..
The PI 3-kinase PI3KC2 alpha regulates mouse platelet membrane structure and function independently of membrane lipid composition
Maria V Selvadurai, Rose J Brazilek, Mitchell J Moon, Jean-Yves Rinckel, Anita Eckly, Christian Gachet, Peter J Meikle, Harshal H Nandurkar, Warwick S Nesbitt, Justin R Hamilton
PI3KC2α is a phosphoinositide 3-kinase with a recently reported function in platelets; PI3KC2α-deficient mouse platelets have alte..