TARGETING OXIDANT-DEPENDENT PATHWAYS TO IMPROVE STROKE OUTCOMES IN COPD

Grant number: 1120522 | Funding period: 2017 - 2020

Completed

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th largest cause of death worldwide. Patients with COPD are at increased risk for stroke and this is even higher in the weeks following a lung viral infection. The reason for this is unknown so the aim of this study is to determine why people with COPD are at increased risk for stroke and then develop novel treatments to prevent or reduce stroke in COPD patients.

Related publications (6)

Scholarly works icon

Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Kurt Brassington, Stanley MH Chan, Simone N De Luca, Aleksandar Dobric, Suleman A Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos

2022-04-01

People with chronic obstructive pulmonary disease (COPD) are susceptible to respiratory infections which exacerbate pulmonary and/..

Scholarly works icon

Ebselen reduces cigarette smoke-induced vascular endothelial dysfunction in mice

Kurt Brassington, Stanley MH Chan, Huei Jiunn Seow, Aleksandar Dobric, Steven Bozinovski, Stavros Selemidis, Ross Vlahos

2021-02-27

BACKGROUND AND PURPOSE: It is well established that both smokers and patients with COPD are at a significantly heightened risk of ..

Scholarly works icon

Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation

Ashton Bernard, Jacqueline M Ku, Ross Vlahos, Alyson A Miller

2019-10-30

Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies have shown that cigarette smoke e..

Scholarly works icon

Prior cigarette smoke exposure does not affect acute post-stroke outcomes in mice

Victoria Austin, Alyson Miller, Ross Vlahos

2019-03-21

Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death globally and is characterized by airflo..

Scholarly works icon

Ischaemic stroke in mice induces lung inflammation but not acute lung injury

Victoria Austin, Jacqueline M Ku, Alyson A Miller, Ross Vlahos

2019-03-06

Stroke is a major cause of death worldwide and ischemic stroke is the most common subtype accounting for approximately 80% of all ..

Scholarly works icon

The PI 3-kinase PI3KC2 alpha regulates mouse platelet membrane structure and function independently of membrane lipid composition

Maria V Selvadurai, Rose J Brazilek, Mitchell J Moon, Jean-Yves Rinckel, Anita Eckly, Christian Gachet, Peter J Meikle, Harshal H Nandurkar, Warwick S Nesbitt, Justin R Hamilton

2019-01-01

PI3KC2α is a phosphoinositide 3-kinase with a recently reported function in platelets; PI3KC2α-deficient mouse platelets have alte..

University of Melbourne Researchers