The Anti-Cancer Potential of Human Gamma Delta T Cells

Butyrophilin 3A1 engages the CDR2δ loop of the Vγ9Vδ2 T cell receptor

TS Fulford, M Rigau, JZ Yang, Z Ruan, KC Singgih, C Soliman, SJ Redmond, T Zhang, HF Koay, X Ma, Y Zhang, NA Gherardin, DI Godfrey, AP Uldrich

2026-09-22

Phosphoantigen (pAg) recognition by Vγ9Vδ2⁺ T cells plays a critical role in immunity to pathogens and cancer. The buty..

Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

TS Fulford, C Soliman, RG Castle, M Rigau, Z Ruan, O Dolezal, R Seneviratna, HG Brown, E Hanssen, A Hammet, S Li, SJ Redmond, A Chung, MA Gorman, MW Parker, O Patel, TS Peat, J Newman, A Behren, NA Gherardin

2024-08-01

Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses ..