Defining The Molecular Mechanisms Of Lyssavirus Replication And Immune Evasion: The P Protein Axis

Grant number: 1125704 | Funding period: 2017 - 2021

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Abstract

Lyssaviruses such as rabies virus (RABV) and Australian bat lyssavirus cause rabies disease, which has the highest case-fatality rate of known infectious diseases, causing >60,000 human deaths/year. Critical to this is a protein produced by the virus that is important for both viral growth and evasion of the host's immune defences. This project aims to understand the molecular mechanisms underlying these processes, which may lead to new approaches to combat currently incurable viral diseases.