BRIDGING THE GAP IN KIDNEY TRANSPLANTATION USING PIGS AS DONORS
Grant number: 1120443 | Funding period: 2017 - 2020
Chronic kidney failure results in patients suffering significant morbidity and mortality ultimately requiring life-supporting dialysis. Kidney transplantation and lifelong immunosuppression are the only treatment, but (i) is limited by the shortage of human donors and (ii) carries risks associated with these anti-rejection drugs. This project aims to solve both problems by using humanized pigs as donors combined with a novel approach to inducing acceptance of the transplanted kidneys.
Related publications (2)
FokI-dCas9 mediates high-fidelity genome editing in pigs
Nella Fisicaro, Evelyn J Salvaris, Gayle K Philip, Matthew J Wakefield, Mark B Nottle, Wayne J Hawthorne, Peter J Cowan
Gene editing using clustered regularly interspaced short palindromic repeats/Cas9 has great potential for improving the compatibil..